Since its completion, the National Advanced Driving Simulator (NADS) has been used for a variety of NHTSA research projects. NHTSA-sponsored research using the NADS has spanned a variety of topics including driver distraction, drivers’ responses to vehicle component failures, and the effects of alcohol impairment on driving performance. The validity of the NADS has also been verified empirically. The NADS provides the computational capabilities and fidelity necessary to create complex driving situations with varying task demands with high repeatability. The use of the NADS also allows the inclusion of conflict situations that cannot safely be created in on-road experiments. NHTSA research utilizes these unique capabilities of NADS to address questions that cannot be addressed with on-road or test-track experimentation. This paper highlights NADS capabilities through descriptions of NHTSA research programs.