The injury characteristics of tempered and laminated side glazing during collisions are analyzed. This study is based upon a comprehensive literature review, fundamental design analysis, and the results of numerous statistical studies with particular emphasis on the injury rates associated with the tempered and HPR laminated windscreens that were used concurrently in Europe in the late 1960s and 1970s. Comparative aspects of laceration, ejection, impact, eye injury, and entrapment are detailed. It is shown that the occupant is most seriously threatened by partial or complete ejection which can be effectively mitigated by laminated glazing. It is also shown that the most common glazing-related injury is laceration, the incidence of which is also reduced by laminated glazing. Injury statistics conclusively demonstrate that for each injury mechanism studied, laminated side glazing offers superior occupant protection. The relative merits of the two glazing materials are discussed from the cost, security, and comfort/convenience perspectives. The results of testing of currently marketed side glazing technology are also presented. The study is limited by the disproportionate use of tempered side glazing in vehicles on the roadway at the time of writing, and that instances of laminated side glazing preventing ejection related serious injuries are not fully reported. New contributions include the comprehensive nature of the study, testing, and analysis.