Neural stem and progenitor cells (together termed neural precursors) (NPCs) are found in neurogenic regions of the adult brain. Their presence at injury sites has been shown to correlate with neural repair. NPCs are electrosensitive cells and undergo rapid and directed migration towards the cathode in vitro. The overall goal of this thesis is to investigate the use of electrical stimulation to promote precursor cell migration to improve healing. We first asked if NPC migration can be directed by electrical stimulation in vivo. We designed an electrode to direct NPC migration in vivo and transplanted NPCs on the corpus callosum in the mouse brain. We placed the cathode medial to the injection site and used biphasic monopolar electrical stimulation to promote NPC migration medially in stimulated brains compared to non-stimulated brains. We first observed that transplanted NPCs have a propensity to migrate laterally along the corpus callous, irrespective of stimulation. Interestingly, we found that this lateral migration correlated with the presence of an endogenous negative potential lateral to the injection site. With regard to an applied electric field, our stimulation paradigm following cell transplantation did provide a significant, albeit small, medial migration. Thus, we propose that endogenous electric fields are present in the brain and need to be over-ridden when directing cell migration in vivo. With a view towards understanding the potential for EF application to promote tissue repair in general, we asked whether directed migration in applied EFs is a general property of precursor cells. We examined the galvanotactic response of skin-derived precursor cells (SKPs). We demonstrate that unlike NPCs, SKPs undergo directed migration towards the anode in the presence of an EF in vitro in a substrate dependent manner. Further, SKP galvanotactic responsiveness is dependent on factors released from neighbouring cells. This research demonstrates the potential for electrical stimulation to serve as a tool to direct precursor cell migration in vivo and highlights the importance of considering the microenvironment for EF application.