Regenerative medicine is an interdisciplinary field of medicine that develops methodologies to replace damaged or diseased cells. The recent understanding that neural precursor cell (NPC) behaviour is controlled by signaling from their micro-environment has been at the forefront of development for neurological therapies. The application of electric fields has been shown to promote NPC migration and electrodes have been the most used channel by which brain signals have been investigated and manipulated for therapeutic purposes. A challenge facing neural interfacing therapeutics is seamlessly incorporating electrodes that are typically made of rigid and stiff materials with the soft and dynamic nature of the brain where they would be situated. By minimizing this mechanical mismatch, the aim is to attenuate the host’s biological inflammatory response. In this work hydrogel-based materials are explored as potential alternatives to the existing less biocompatible counterparts with the goal of promoting brain repair following injury or disease.