Application of a Thermodynamic-Based Model to Investigate Bone Remodeling After Total Hip Arthroplasty Using Different Hip Implants

A new thermodynamic-based model for bone remodeling is introduced. This model is based on chemical kinetics and irreversible thermodynamics in which bone is treated as a self-organizing system capable of exchanging matter, energy and entropy with its surroundings. Unlike the previous works in which mechanical loading is regarded as the only stimulus for bone remodeling, this model establishes a coupling between mechanical loading and the chemical reactions involved in the process of bone remodeling. This model is then incorporated to the finite element software ANSYS in the form of a macro to study bone remodeling after total hip arthroplasty with four different implants: Custom-made titanium, Composite, Exceter and Omnifit hip stems. Numerical computations of bone density distribution after total hip arthroplasty indicate that the Omnifit implant with carbon fiber polyamide12 composite results in minimum resorption in the proximal femur and consequently minimum bone loss due to stress shielding.

Year	Entry
1992	Weinans H, Huiskes R, Grootenboer HJ. The behavior of adaptive bone-remodeling simulation models. J Biomech. December 1992;25(12):1425-1441.
2005	Ruimerman R. Modeling and Remodeling in Bone Tissue [PhD thesis]. Eindhoven University of Technology; 2005.
1992	Huiskes R, Weinans H, Van Rietbergen B. The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials. Clin Orthop Relat Res. January 1992;274:124-134.
1989	Carter DR, Orr TE, Fyhrie DP. Relationships between loading history and femoral cancellous bone architecture. J Biomech. 1989;22(3):231-244.
1987	Huiskes R, Weinans H, Grootenboer HJ, Dalstra M, Fudala B, Slooff TJ. Adaptive bone-remodeling theory applied to prosthetic-design analysis. J Biomech. 1987;20(11-12):1135-1150.
1990	Fung YC. Biomechanics: Motion, Flow, Stress, and Growth. New York, NY: Springer-Verlag; 1990.
1985	Rubin CT, Lanyon LE. Regulation of bone mass by mechanical strain magnitude. Calcif Tiss Int. 1985;37(4):411-417.
1983	Huiskes R, Chao EYS. A survey of finite element analysis in orthopedic biomechanics: the first decade. J Biomech. 1983;16(6):385-409.
2007	Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg. April 2007;89A(4):780-785.
2000	Huiskes R, Ruimerman R, van Lenthe GH, Janssen JD. Effects of mechanical forces on maintenance and adaptation of form in trabecular bone. Nature. June 8, 2000;405(6787):704-706.
2009	Mahboob Z. A Validated Finite Element Study of Stress Shielding in a Novel Hybrid Knee Implant [Master's thesis]. Ryerson University; 2009.

Year

Entry

1992

Weinans H, Huiskes R, Grootenboer HJ. The behavior of adaptive bone-remodeling simulation models. J Biomech. December 1992;25(12):1425-1441.

2005

Ruimerman R. Modeling and Remodeling in Bone Tissue [PhD thesis]. Eindhoven University of Technology; 2005.

1992

Huiskes R, Weinans H, Van Rietbergen B. The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials. Clin Orthop Relat Res. January 1992;274:124-134.

1989

Carter DR, Orr TE, Fyhrie DP. Relationships between loading history and femoral cancellous bone architecture. J Biomech. 1989;22(3):231-244.

1987

Huiskes R, Weinans H, Grootenboer HJ, Dalstra M, Fudala B, Slooff TJ. Adaptive bone-remodeling theory applied to prosthetic-design analysis. J Biomech. 1987;20(11-12):1135-1150.

1990

Fung YC. Biomechanics: Motion, Flow, Stress, and Growth. New York, NY: Springer-Verlag; 1990.

1985

Rubin CT, Lanyon LE. Regulation of bone mass by mechanical strain magnitude. Calcif Tiss Int. 1985;37(4):411-417.

1983

Huiskes R, Chao EYS. A survey of finite element analysis in orthopedic biomechanics: the first decade. J Biomech. 1983;16(6):385-409.

2007

Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg. April 2007;89A(4):780-785.

2000

Huiskes R, Ruimerman R, van Lenthe GH, Janssen JD. Effects of mechanical forces on maintenance and adaptation of form in trabecular bone. Nature. June 8, 2000;405(6787):704-706.

2009

Mahboob Z. A Validated Finite Element Study of Stress Shielding in a Novel Hybrid Knee Implant [Master's thesis]. Ryerson University; 2009.

Year	Entry
2015	Avval PT. Predicting Bone Remodeling in Response to Orthopedic Implantations: Computational Study Using a Mechano-Biochemical Model [PhD thesis]. Ryerson University; 2015.

Year

Entry

2015

Avval PT. Predicting Bone Remodeling in Response to Orthopedic Implantations: Computational Study Using a Mechano-Biochemical Model [PhD thesis]. Ryerson University; 2015.