Medial collateral ligament healing:​ a multidisciplinary assessment in rabbits

Frank, C.; Woo, S. L-Y.; Amiel, D.; Harwood, F.; Gomez, M.; Akeson, W.

Affiliations

¹Division of Orthopaedic Surgery, University of California, San Diego, and Veterans Administration Medical Center, San Diego, California

Abstract

Medial collateral ligament healing without treatment has been studied in a rabbit model. Complete midsubstance gaps were found to heal by distinct scar formation over time. This healing process was fast since the gap was bridged quickly; however, more subtle changes in ap pearance of the healing tissue continued for many months. The ligament "scar" was found to be structur ally abnormal chemically and mechanically even at long- term followup. A plateau in its improvement suggests that the scar may never approach normal ligament characteristics (without treatment). A baseline of liga ment healing by scar formation has been established.

Links

DOI: 10.1177/036354658301100602

PubMed: 6650715

WoS: A1983RS88500002

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Cited By (29)

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1990	Viidik A. Structure and function of normal and healing tendons and ligaments. In: Mow VC, Ratcliffe A, Woo SL-Y, eds. Biomechanics of Diarthrodial Joints. Vol 1. New York, NY: Springer-Verlag; 1990:3-38.
1990	Woo SL-Y, Weiss JA, MacKenna DA. Biomechanics and morphology of the medial collateral and anterior cruciate ligaments. In: Mow VC, Ratcliffe A, Woo SL-Y, eds. Biomechanics of Diarthrodial Joints. Vol 1. New York, NY: Springer-Verlag; 1990:63-104.
2003	Woo SL-Y, Abramowitch SD, Loh JC, Musahl V, Wang JH-C. Ligament healing: present status and the future of functional tissue engineering. In: Guilak F, Butler DL, Goldstein SA, Mooney DJ, eds. Functional Tissue Engineering. New York, NY: Inc., Springer-Verlag; 2003:17-34.
1992	Woo SL-Y, Ohland KJ, Fu FH. Healing and repair of knee ligaments relating to sports injury. In: Proceedings of the 2nd Injury Prevention Through Biomechanics Symposium. April 10-11, 1992; Detroit, MI.3-6.
1987	Woo SL-Y, Inoue M, McGurk-Burleson E, Gomez MA. Treatment of the medial collateral ligament injury, II: structure and function of canine knees in response to differing treatment regimens. Am J Sports Med. January–February 1987;15(1):22-29.
2001	Provenzano PP, Hurschler C, Vanderby R Jr. Microstructural morphology in the transition region between scar and intact residual segments of a healing rat medial collateral ligament. Connect Tissue Res. 2001;42(2):123-133.
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