Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel

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Wakitani, Shigeyuki¹; Kimura, Tomoatsu¹; Hirooka, Atsushi¹; Ochi, Takahiro¹; Yoneda, Minoru¹; Yasui, Natsuo²; Owaki, Hajime¹; Ono, Keiro¹

Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel

J Bone Joint Surg. January 1989;71B(1):74-80

©1989 British Editorial Society of Bone and Joint Surgery

Affiliations

¹Department of Orthopaedic Surgery, Osaka University Medical School, 1-1-50 Fukushima Fukushima-ku, Osaka 553, Japan

²Department of Orthopaedic Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa 359, Japan
Abstract

In an attempt to repair articular cartilage, allograft articular chondrocytes embedded in collagen gel, were transplanted into full-thickness defects in rabbit articular cartilage. Twenty-four weeks after the transplantation, the defects were filled with hyaline cartilage, specifically synthesising Type II collagen. These chondrocytes were autoradiographically proven to have originated from the transplanted grafts.

Assessed histologically the success rate was about 80%, a marked improvement over the results reported in previous studies on chondrocyte transplantation without collagen gel. By contrast, the defects without chondrocyte transplantation healed with fibrocartilage. Immunological enhancement induced by transplanted allogenic chondrocytes or collagen was not significant at eight weeks after treatment, so far as shown by both direct and indirect blastformation reactions. Thus, allogenic transplantation of isolated chondrocytes embedded in collagen gel appears to be one of the most promising methods for the restoration of articular cartilage.
Links

DOI: 10.1302/0301-620X.71B1.2915011

PubMed: 2915011

WoS: A1989R842600021

Cited By (30)

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