CoCrMo alloys are well-established biomaterials used for orthopedic joint replacement implants. However, such alloys have been associated with clinical problems related to wear and corrosion. A new generation of austenitic high-nitrogen steels (AHNSs) has been developed for biomedical applications. Here, we have addressed influences of hyaluronic acid, combined with inflammatory (oxidizing) conditions, on tribocorrosion of the high-nitrogen FeCrMnMoN_0.9 steel (DIN/EN X13CrMnMoN18-14-3, 1.4452), and of the low carbon CoCrMo_0.03 alloy (ISO 5832-12). We aimed to elucidate critical and clinically relevant conditions affecting the implant's performance in certain orthopedic applications. Tribocorrosion tests were conducted in triplicate, with discs under reciprocating sliding wear against a ceramic ball. Different lubricants were prepared from standardized bovine serum solution (ISO 14242-1), with variable additions of hyaluronic acid (HA) and hydrogen peroxide (H₂O₂). Test conditions were:​ 37°C, 86,400 cycles, 37 N load (20–40 MPa after run-in phase). Volumetric wear was quantified;​ surfaces were evaluated by electrochemical parameters and microscopy/spectroscopy analyses (SEM/EDS). Factorial analysis of variance tests was conducted to examine the effects of HA, H₂O₂, and test material on wear- and corrosion-related dependent variables. Tribocorrosion performances of CoCrMo_0.03 and FeCrMnMoN_0.9 were comparable in fluids without H₂O₂. With higher H₂O₂ concentrations, tribocorrosion increased for CoCrMo_0.03, while this was not the case for FeCrMnMoN_0.9. HA significantly enhanced wear of CoCrMo_0.03 in the absence of H₂O₂, while it mitigated the tribocorrosive action of 3 mM H₂O₂;​ HA had no impact on FeCrMnMoN_0.9. These results indicate a favorable performance of FeCrMnMoN_0.9 compared to CoCrMo_0.03, and encourage further research on AHNS for certain orthopedic applications.