Analysis of acute mechanical insult in an animal model of post-traumatic osteoarthrosis

Newberry, W. N.; Garcia, J. J.; Mackenzie, C. D.; Decamp, C. E.; Haut, R. C.

Affiliations

¹Orthopaedic Biomechanics Laboratories, College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824

²Department of Pathology, Colleges of Osteopathic Medicine and Veterinary Medicine, Michigan State University, East Lansing, MI 48824

³Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824

Abstract

Chronic degeneration of articular cartilage and bone in a rabbit model of post-traumatic osteoarthrosis has been hypothesized to occur due to acute stresses that exceed a threshold for injury. In this study, we impacted the rabbit patellofemoral joint at low and high intensities. High-intensity impacts produced degenerative changes in the joint, such as softening of retropatellar cartilage, as measured by indentation, an increase in histopathology of the cartilage, and an increase in thickness of sub-chondral bone underlying the cartilage. Low-intensity impacts did not cause these progressive changes. These data suggest that low-intensity impacts produced acute tissue stresses below the injury threshold, while high-intensity impacts produced stresses that exceeded the threshold for disease pathogenesis. This study begins to identify “safe” and “unsafe” ranges of acute tissue stress, using the rabbit patella, which may have future utility in the design of injury prevention devices for the human.

Links

DOI: 10.1115/1.2834882

PubMed: 10412452

WoS: 000077716900003

History

Received: 1998-02-12

Revised: 1998-07-22

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Cited By (23)

Year	Entry
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2008	Natoli RM. Impact Loading and Functional Tissue Engineering of Articular Cartilage [PhD thesis]. Houston, TX: Rice University; October 2008.
2013	Nishimuta JF. Degradation of Cartilage and Meniscus Tissues: An in Vitro Investigation in Osteoarthritis Development [PhD thesis]. Stanford University; March 2013.
2000	Kralovic BJ. The Effects of Patellofemoral Kinematics on Joint Congruence and Cartilage Stresses [Master's thesis]. Calgary, AB: University of Calgary; January 2000.
2013	Henak CR. Cartilage and Labrum Mechanics in the Normal and Pathomorphologic Human Hip [PhD thesis]. University of Utah; August 2013.
2005	Rudd RW. Injury Tolerance of the Human Ankle in Impact-Induced Dorsiflexion [PhD thesis]. Charlottesville, VA: University of Virginia; January 2005.
2008	Kerrigan JR. A Computationally Efficient Mathematical Model of the Pedestrian Lower Extremity [PhD thesis]. Charlottesville, VA: University of Virginia; January 2008.