Cortical bone structure of the proximal femur and incident fractures

Nissen, Frida Igland; Andreasen, Camilla; Borgen, Tove Tveitan; Bjørnerem, Åshild; Hansen, Ann Kristin

Affiliations

¹Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway

²Department of Orthopedic Surgery, University Hospital of North Norway, Tromsø, Norway

³Department of Obstetrics and Gynecology, University Hospital of North Norway, Tromsø, Norway

⁴Department of Rheumatology, Vestre Viken Hospital Trust, Drammen Hospital, Drammen, Norway

⁵Norwegian Research Centre for Women's Health, Oslo University Hospital, Oslo, Norway

Abstract and keywords

Purpose: Fracture risk is most frequently assessed using Dual X-ray absorptiometry to measure areal bone mineral density (aBMD) and using the Fracture Risk Assessment Tool (FRAX). However, these approaches have limitations and additional bone measurements may enhance the predictive ability of these existing tools. Increased cortical porosity has been associated with incident fracture in some studies, but not in others. In this prospective study, we examined whether cortical bone structure of the proximal femur predicts incident fractures independent of aBMD and FRAX score.

Methods: We pooled 211 postmenopausal women with fractures aged 54–94 years at baseline and 232 fracture-free age-matched controls based on a prior nested case-control study from the Tromsø Study in Norway. We assessed baseline femoral neck (FN) aBMD, calculated FRAX 10-year probability of major osteoporotic fracture (MOF), and quantified femoral subtrochanteric cortical parameters: porosity, area, thickness, and volumetric BMD (vBMD) from CT images using the StrAx1.0 software. Associations between bone parameters and any incident fracture, MOF and hip fracture were determined using Cox's proportional hazard models to calculate hazard ratio (HR) with 95% confidence interval.

Results: During a median follow-up of 7.2 years, 114 (25.7%) of 443 women suffered one or more incident fracture. Cortical bone structure did not predict any incident fracture or MOF after adjustment for age, BMI, and previous fracture. Each SD higher total cortical porosity, thinner cortices, and lower cortical vBMD predicted hip fracture with increased risk of 46–62% (HRs ranging from 1.46 (1.01–2.11) to 1.62 (1.02–2.57)). After adjustment for FN aBMD or FRAX score no association remained significant. Both lower FN aBMD and higher FRAX score predicted any incident fracture, MOF and hip fractures with HRs ranging from 1.45–2.56.

Conclusions: This study showed that cortical bone measurements using clinical CT did not add substantial insight into fracture risk beyond FN aBMD and FRAX. We infer from these results that fracture risk related to the deteriorated bone structure seems to be largely captured by a measurement of FN aBMD and the FRAX tool.

Keywords: Bone fragility; Cortical bone structure; Fracture risk; Osteoporosis; Postmenopausal women

Links

DOI: 10.1016/j.bone.2021.116284

PubMed: 34875395

WoS: 000773552300009

History

Received: 2021-07-9

Revised: 2021-11-29

Accepted: 2021-12-1

Online: 2021-12-4

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