Mineral maturity and crystallinity index are distinct characteristics of bone mineral

wbldb

Farlay, Delphine¹; Panczer, Gérard²; Rey, Christian³; Delmas, Pierre D.; Boivin, Georges¹

Mineral maturity and crystallinity index are distinct characteristics of bone mineral

J Bone Min Metab. July 2010;28(4):433-445

©2010 The Japanese Society for Bone and Mineral Research and Springer

Affiliations

¹Faculté de Médecine R. Laennec, INSERM Unité 831, Université de Lyon, Rue Guillaume Paradin, 69372 Lyon Cedex 08, France

²CECOMO, Université de Lyon, Campus de la Doua, Villeurbanne, France

³ENSIACET, Toulouse, France
Abstract and keywords

The purpose of this study was to test the hypothesis that mineral maturity and crystallinity index are two different characteristics of bone mineral. To this end, Fourier transform infrared microspectroscopy (FTIRM) was used. To test our hypothesis, synthetic apatites and human bone samples were used for the validation of the two parameters using FTIRM. Iliac crest samples from seven human controls and two with skeletal fluorosis were analyzed at the bone structural unit (BSU) level by FTIRM on sections 2–4 μm thick. Mineral maturity and crystallinity index were highly correlated in synthetic apatites but poorly correlated in normal human bone. In skeletal fluorosis, crystallinity index was increased and maturity decreased, supporting the fact of separate measurement of these two parameters. Moreover, results obtained in fluorosis suggested that mineral characteristics can be modified independently of bone remodeling. In conclusion, mineral maturity and crystallinity index are two different parameters measured separately by FTIRM and offering new perspectives to assess bone mineral traits in osteoporosis.

Keywords: Bone mineral; Hydrated layer; FTIRM; Mineral maturity; Mineral crystallinity index
Links

DOI: 10.1007/s00774-009-0146-7

PubMed: 20091325

WoS: 000279210500008
History

Received: 2009-07-29

Accepted: 2009-11-17

Online: 2010-01-22

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