Site-specific effects of strength training on bone structure and geometry of ultradistal radius in postmenopausal women

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Adami, Silvano¹; Gatti, Davide¹; Braga, Vania¹; Bianchini, Donatella¹; Rossini, Maurizio¹

Site-specific effects of strength training on bone structure and geometry of ultradistal radius in postmenopausal women

J Bone Miner Res. January 1999;14(1):120-124

©1999 American Society for Bone and Mineral Research

Affiliations

¹Istituto di Smeiotica e Nefrologia Medica, University of Verona, Italy
Abstract

Knowledge of the effects of exercise on bone mass in postmenopausal women is limited and controversial. Animal studies have shown that the response of bone to bending strain is an alteration of bone geometry. We studied 250 postmenopausal women, aged 52–72 years, willing to participate in a 6-month exercise program. The first 125 started the program immediately and the remaining 125 served as controls. The training program included exercises designed to maximize the stress on the wrist. One hundred and eighteen of the active group and 116 of the control group completed the study and were reassessed 6 months later. Bone mineral density (BMD) of the femoral neck, lumbar spine, ultradistal and proximal radius was measured by dual-energy X-ray absorptiometry (DXA) both before and at the end of the exercise program. The forearm was also evaluated by peripheral quantitative computed tomography, which measures the area, bone mineral content (BMC), and volumetric density for both the cortical and the trabecular component. The results showed that the DXA measurements at the femoral neck, lumbar spine, ultradistal and proximal radius were similar between the two groups. No significant difference was detected after the exercise program at the proximal radius. At the ultradistal radius, the cross-sectional area of cortical bone rose by 2.8 ± 15.0% (SD, p < 0.05), apparently for both periosteal apposition and corticalization of the trabecular tissue. The volumetric density of cortical bone rose by 2.2 ± 15.8% (p < 0.1), and that of trabecular bone decreased by 2.6 ± 10.7% (p < 0.01). The combined changes in both bone volume and density in the exercise group were associated with marked increase in cortical BMC (3.1 ± 10.7%, p < 0.01) and decrease in trabecular BMC (−3.4 ± 14.2%, p < 0.05), which were statistically different from those observed in the control group (p < 0.05). In conclusion, these results confirm that site-specific moderate physical exercises have very little effect on bone mass. However, it appears that some exercises may reshape the bone segment under stress by increasing both the cross-sectional area and the density of the cortical component. These structural changes are theoretically associated with increases in the bending strength.
Links

DOI: 10.1359/jbmr.1999.14.1.120

PubMed: 9893073

WoS: 000077715800016
History

Received: 1998-02-24

Revised: 1998-08-14

Accepted: 1998-09-06

Cited Works (8)

Year	Entry
1997	Kohrt WM, Ehsani AA, Birge SJ. Effects of exercise involving predominantly either joint-reaction or ground-reaction forces on bone mineral density in older women. J Bone Miner Res. August 1997;12(8):1253-1261.
1982	Lanyon LE, Goodship AE, Pye CJ, MacFie JH. Mechanically adaptive bone remodelling. J Biomech. 1982;15(3):141-154.
1997	Gross TS, Edwards JL, Mcleod KJ, Rubin CT. Strain gradients correlate with sites of periosteal bone formation. J Bone Miner Res. June 1997;12(6):982-988.
1993	Faulkner KG, Cummings SR, Black D, Palermo L, Glüer C, Genant HK. Simple measurement of femoral geometry predicts hip fracture: the study of osteoporotic fractures. J Bone Miner Res. September 1993;8(10):1211-1217.
1994	Nelson ME, Fiatarone MA, Morganti CM, Trice I, Greenberg RA, Evans WJ. Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures: a randomized controlled trial. JAMA. December 28, 1994;271(24):1909-1914.
1988	Dalsky GP, Stocke KS, Ehsani AA, Slatopolsky E, Lee WC, Birge SJ Jr. Weight-bearing exercise training and lumbar bone mineral content in postmenopausal women. Ann Intern Med. June 1988;108(6):824-828.
1996	Kerr D, Morton A, Dick I, Prince R. Exercise effects on bone mass in postmenopausal women are site-specific and load-dependent. J Bone Miner Res. February 1996;11(2):218-225.
1992	Akhter MP, Raab DM, Turner CH, Kimmel DB, Recker RR. Characterization of in vivo strain in the rat tibia during external application of a four-point bending load. J Biomech. October 1992;25(10):1241-1246.

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2020	Lambert C, Beck BR, Harding AT, Watson SL, Weeks BK. Regional changes in indices of bone strength of upper and lower limbs in response to high-intensity impact loading or high-intensity resistance training. Bone. March 2020;132:115192.
2020	Harding AT, Weeks BK, Lambert C, Watson SL, Weis LJ, Beck BR. Effects of supervised high-intensity resistance and impact training or machine-based isometric training on regional bone geometry and strength in middle-aged and older men with low bone mass: the LIFTMOR-M semi-randomised controlled trial. Bone. July 2020;136:115362.
2021	Kistler-Fischbacher M, Weeks BK, Beck BR. The effect of exercise intensity on bone in postmenopausal women (part 1): a systematic review. Bone. February 2021;143:115696.
2020	Kemmler W, Shojaa M, Kohl M, Stengel Sv. Effects of different types of exercise on bone mineral density in postmenopausal women: a systematic review and meta-analysis. Calcif Tiss Int. November 2020;107(5):409-439.
2007	Troy KL, Grabiner MD. Off-axis loads cause failure of the distal radius at lower magnitudes than axial loads: a finite element analysis. J Biomech. 2007;40(8):1670-1675.
2002	Petit MA, Mckay HA, MacKelvie KJ, Heinonen A, Khan KM, Beck TJ. A randomized school-based jumping intervention confers site and maturity-specific benefits on bone structural properties in girls: a hip structural analysis study. J Bone Miner Res. March 2002;17(3):363-372.
2002	Kontulainen S, Sievänen H, Kannus P, Pasanen M, Vuori I. Effect of long‐term impact‐loading on mass, size, and estimated strength of humerus and radius of female racquet‐sports players: a peripheral quantitative computed tomography study between young and old starters and controls. J Bone Miner Res. December 2002;17(12):2281-2289.
2005	Warden SJ, Hurst JA, Sanders MS, Turner CH, Burr DB, Li J. Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance. J Bone Miner Res. May 2005;20(5):809-816.
2006	Lang TF, Leblanc AD, Evans HJ, Lu Y. Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight. J Bone Miner Res. August 2006;21(8):1224-1230.
2023	Ng C-A, Gandham A, Mesinovic J, Owen PJ, Ebeling PR, Scott D. Effects of moderate- to high-impact exercise training on bone structure across the lifespan: a systematic review and meta-analysis of randomized controlled trials. J Bone Miner Res. November 2023;38(11):1612-1634.
2008	Engelke K, Adams JE, Armbrecht G, Augat P, Bogado CE, Bouxsein ML, Felsenberg D, Ito M, Prevrhal S, Hans DB, Lewiecki EM. Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD official positions. J Clin Densitom. January–March 2008;11(1):123-162.
2014	Fonseca H, Moreira-Gonçalves D, Coriolano H-JA, Duarte JA. Bone quality: the determinants of bone strength and fragility. Sports Med. January 2014;44(1):37-53.
2019	Harding A. LIFTMOR-M: Lifting Intervention for Training Muscle and Osteoporosis Rehabilitation for Men [PhD thesis]. Brisbane, Australia: Griffith University; December 2019.
2019	Lambert C. A Comparison of the Bone Response to Impact Loading and Resistance Training in Young Adult Women: The OPTIMA-Ex Trial [PhD thesis]. Brisbane, Australia: Griffith University; July 2019.
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2002	Kontulainen S. Training, Detraining and Bone: Effect of Exercise on Bone Mass and Structure With Special Reference to Maintenance of the Exercise-Induced Bone Gain [PhD thesis]. University of Jyväskylä; 2002.
2005	Ashe MC. Upper Limb Bone Health: Cadaveric, Imaging and Clinical Studies With Special Emphasis on Peripheral Quantitative Computed Tomography [PhD thesis]. Vancouver, BC: University of British Columbia; April 2005.
2005	Manske SL. Magnetic Resonance Imaging as an Instrument to Assess the Association Between Femoral Neck Bone Geometry and Strength of the Proximal Femur [Master's thesis]. Vancouver, BC: University of British Columbia; October 2005.
2013	Bhatia V. Loading Induced Bone Adaptation in the Distal Radius of Women: Influence of Mechanical Environment [PhD thesis]. University of Illinois at Chicago; 2013.
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2010	Erlandson MC. The Relationship of Gymnastics Participation in Childhood and Adolescence to Skeletal Development and Maintenance [PhD thesis]. University of Saskatchewan; September 2010.
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