Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws:​ a growing epidemic

Marx, Robert E.

Year	Entry
2011	Baron R, Ferrari S, Russell RGG. Denosumab and bisphosphonates: different mechanisms of action and effects. Bone. April 2011;48(4):677-692.
2020	Messer JG, Castillo EJ, Abraham AM, Jiron JM, Israel R, Yarrow JF, Thomas S, Reynolds MC, Wnek RD, Jorgensen M, Wanionok N, Van Poznak C, Bhattacharyya I, Kimmel DB, Aguirre JI. Anti-vascular endothelial growth factor antibody monotherapy causes destructive advanced periodontitis in rice rats (Oryzomys palustris). Bone. January 2020;130:115141.
2020	Hayano H, Kuroshima S, Sasaki M, Tamaki S, Inoue M, Ishisaki A, Sawase T. Distinct immunopathology in the early stages between different antiresorptives-related osteonecrosis of the jaw-like lesions in mice. Bone. June 2020;135:115308.
2020	Coleman R. Bisphosphonates and breast cancer: from cautious palliation to saving lives. Bone. November 2020;140:115570.
2020	Govaerts D, Piccart F, Ockerman A, Coropciuc R, Politis C, Jacobs R. Adjuvant therapies for MRONJ: a systematic review. Bone. December 2020;141:115676.
2021	Gao S-y, Lin R-b, Huang S-h, Liang Y-j, Li X, Zhang S-e, Ouyang D-q, Li K, Zheng G-s, Liao G-q. PDGF-BB exhibited therapeutic effects on rat model of bisphosphonate-related osteonecrosis of the jaw by enhancing angiogenesis and osteogenesis. Bone. March 2021;144:115117.
2021	Fuggle NR, Curtis B, Clynes M, Zhang J, Ward K, Javaid MK, Harvey NC, Dennison E, Cooper C. The treatment gap: the missed opportunities for osteoporosis therapy. Bone. March 2021;144:115833.
2021	Sedghizadeh PP, Sun S, Jones AC, Sodagar E, Cherian P, Chen C, Junka AF, Neighbors JD, McKenna CE, Russell RGG, Ebetino FH. Bisphosphonates in dentistry: historical perspectives, adverse effects, and novel applications. Bone. June 2021;147:115933.
2021	Inoue M, Matsumoto C, Nakajima K, Kuroshima S, Sawase T. Alendronate/dexamethasone combination therapy worsens soft and hard tissue wound healing around implants in rat maxillae. Bone. July 2021;148:115942.
2022	Jara MA, Varghese J, Hu MI. Adverse events associated with bone-directed therapies in patients with cancer. Bone. May 2022;158:115901.
2023	Coropciuc R, Coopman R, Garip M, Gielen E, Politis C, Van den Wyngaert T, Beuselinck B. Risk of medication-related osteonecrosis of the jaw after dental extractions in patients receiving antiresorptive agents: a retrospective study of 240 patients. Bone. May 2023;170:116722.
2023	Kanno C, Kojima M, Tezuka Y, Yaginuma S, Kanaya Y, Kaneko T. Antiresorptive agent-related osteonecrosis of the jaw risk in cancer patients before bone-modifying agent therapy: a retrospective study of 511 patients. Bone. December 2023;177:116892.
2023	Kozutsumi R, Kuroshima S, Al-Omari FA, Hayano H, Nakajima K, Kakehashi H, Sawase T. Depletion of macrophages deteriorates bisphosphonate-related osteonecrosis of the jaw-like lesions in mice. Bone. December 2023;177:116899.
2015	Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, Watts NB, Brandi ML, Peters E, Guise T, Eastell R, Cheung AM, Morin SN, Masri B, Cooper C, Morgan SL, Obermayer-Pietsch B, Langdahl BL, Al Dabagh R, Davison KS, Kendler DL, Sándor GK, Josse RG, Bhandari M, El Rabbany M, Pierroz DD, Sulimani R, Saunders DP, Brown JP, Compston J; International Task Force on Osteonecrosis of the Jaw. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. January 2015;30(1):3-23.
2019	Hadaya D, Gkouveris I, Soundia A, Bezouglaia O, Boyce RW, Stolina M, Dwyer D, Dry SM, Pirih FQ, Aghaloo TL, Tetradis S. Clinically relevant doses of sclerostin antibody do not induce osteonecrosis of the jaw (ONJ) in rats with experimental periodontitis. J Bone Miner Res. January 2019;34(1):171-181.
2020	Conley RB, Adib G, Adler RA, Åkesson KE, Alexander IM, Amenta KC, Blank RD, Brox WT, Carmody EE, Chapman‐Novakofski K, Clarke BL, Cody KM, Cooper C, Crandall CJ, Dirschl DR, Eagen TJ, Elderkin AL, Fujita M, Greenspan SL, Halbout P, Hochberg MC, Javaid M, Jeray KJ, Kearns AE, King T, Koinis TF, Koontz JS, Kužma M, Lindsey C, Lorentzon M, Lyritis GP, Michaud LB, Miciano A, Morin SN, Mujahid N, Napoli N, Olenginski TP, Puzas JE, Rizou S, Rosen CJ, Saag K, Thompson E, Tosi LL, Tracer H, Khosla S, Kiel DP. Secondary fracture prevention: consensus clinical recommendations from a multistakeholder coalition. J Bone Miner Res. January 2020;35(1):36-52.
2020	Nordström P, Bergman J, Ballin M, Björk S, Nordström A. Bone‐specific drugs and osteonecrosis of sites other than the jaw: a nationwide cohort study. J Bone Miner Res. September 2020;35(9):1703-1710.
2020	Otto S, Pautke C, Arens D, Poxleitner P, Eberli U, Nehrbass D, Zeiter S, Stoddart MJ. A drug holiday reduces the frequency and severity of medication‐related osteonecrosis of the jaw in a minipig model. J Bone Miner Res. November 2020;35(11):2179-2192.
2021	Yang G, Collins JM, Rafiee R, Singh S, Langaee T, McDonough CW, Holliday LS, Wang D, Lamba JK, Kim YS, Pelliccioni GA, Vaszilko M, Kosa JP, Balla B, Lakatos PA, Katz J, Moreb J, Gong Y. SIRT1 gene SNP rs932658 is associated with medication‐related osteonecrosis of the jaw. J Bone Miner Res. February 2021;36(2):347-356.
2022	Everts-Graber J, Lehmann D, Burkard J-P, Schaller B, Gahl B, Häuselmann H, Studer U, Ziswiler H-R, Reichenbach S, Lehmann T. Risk of osteonecrosis of the jaw under denosumab compared to bisphosphonates in patients with osteoporosis. J Bone Miner Res. February 2022;37(2):340-348.
2022	Spasic M, Duffy MP, Jacobs CR. Fenoldopam sensitizes primary cilia-mediated mechanosensing to promote osteogenic intercellular signaling and whole bone adaptation. J Bone Miner Res. May 2022;37(5):972-982.
2022	Williams DW, Ho K, Lenon A, Kim S, Kim T, Gwack Y, Kim RH. Long-term ligature-induced periodontitis exacerbates development of bisphosphonate-related osteonecrosis of the jaw in mice. J Bone Miner Res. July 2022;37(7):1400-1410.
2019	Eastell R, Rosen CJ, Black DM, Cheung AM, Murad MH, Shoback D. Pharmacological management of osteoporosis in postmenopausal women: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. May 2019;104(5):1595-1622.
2014	Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O'Ryan F. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw: 2014 update. J Oral Maxillofac Surg. October 2014;72(10):1938-1956.
2006	Sambrook P, Cooper C. Osteoporosis. Lancet. June 17, 2006;367(9527):2010-2018.
2008	Drake MT, Clarke BL, Khosla S. Bisphosphonates: mechanism of action and role in clinical practice. Mayo Clin Proc. September 2008;83(9):1032-1045.
2020	Koide M, Yamashita T, Murakami K, Uehara S, Nakamura K, Nakamura M, Matsushita M, Ara T, Yasuda H, Penninger JM, Takahashi N, Udagawa N, Kobayashi Y. Sclerostin expression in trabecular bone is downregulated by osteoclasts. Sci Rep. 2020;10:13751.
2006	Poole KES. The Effects of Stroke on the Skeleton [PhD thesis]. Cambridge, UK: University of Cambridge; 2006.
2020	Mehraban Alvandi L. Diffuse Damage Repair Mechanism in Bone [PhD thesis]. New York, NY: The City College of New York; 2020.
2018	Spasic M. Targeting Primary Cilia-Mediated Mechanotransduction to Promote Whole Bone Formation [PhD thesis]. Columbia University; 2018.
2021	Duffy MP. The Osteocyte Primary Cilium is a Mechanoresponsive Organelle That Regulates Cytoskeletal Adaptation and Coordinates Mechanotransduction With Adenylyl Cyclases [PhD thesis]. Columbia University; 2021.
2023	Ning B. In Vivo Experimental Platform Evaluating Synchronously 3D Bone Growth, (re)modeling, Microdamage and Mechanical Properties [PhD thesis]. École polytechnique de Montréal; August 2023.
2009	Litzenberger JB. The Role of Integrin Signaling in Bone Mechanotransduction [PhD thesis]. Stanford University; 2009.
2014	Kaipatur NR. Impact of Bisphosphonate Bone Burden on Orthodontic Tooth Movement [PhD thesis]. Edmonton, AB: University of Alberta; 2014.
2020	Hadaya D. Osteonecrosis of the Jaws: Investigations Into Pathophysiology and Prevention [PhD thesis]. Los Angeles (UCLA), University of California; 2020.
2014	Hu Z. The Development of a Digital X-Ray Imaging System for the Characterization of Transmission of Whole-Body Vibration in Mice [Master's thesis]. London, ON: Western University; 2014.
2007	Christiansen BA. Vibrational Stimulation of Bone Formation in Mice [PhD thesis]. St. Louis, MO: Washington University in St. Louis; December 2007.