Evidence for ongoing modeling-based bone formation in human femoral head trabeculae via forming minimodeling structures:​ a study in patients with fractures and arthritis

Sano, Hiroshige; Kondo, Naoki; Shimakura, Taketoshi; Fujisawa, Junichi; Kijima, Yasufumi; Kanai, Tomotake; Poole, Kenneth E. S.; Yamamoto, Noriaki; Takahashi, Hideaki E.; Endo, Naoto

Affiliations

¹Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan

²Niigata Bone Science Institute, Niigata, Japan

³Department of Medicine, University of Cambridge, Cambridge, United Kingdom

⁴Department of Orthopedic Surgery, Niigata Rehabilitation Hospital, Niigata, Japan

Abstract and keywords

Bone modeling is a biological process of bone formation that adapts bone size and shape to mechanical loads, especially during childhood and adolescence. Bone modeling in cortical bone can be easily detected using sequential radiographic images, while its assessment in trabecular bone is challenging. Here, we performed histomorphometric analysis in 21 bone specimens from biopsies collected during hip arthroplasty, and we proposed the criteria for histologically identifying an active modeling-based bone formation, which we call a “forming minimodeling structure” (FMiS). Evidence of FMiSs was found in 9 of 20 specimens (45%). In histomorphometric analysis, bone volume was significant higher in specimens displaying FMiSs compared with the specimens without these structures (BV/TV, 31.7 ± 10.2 vs. 23.1 ± 3.9%; p < 0.05). Osteoid parameters were raised in FMiS-containing bone specimens (OV/BV, 2.1 ± 1.6 vs. 0.6 ± 0.3%; p < 0.001, OS/BS, 23.6 ± 15.5 vs. 7.6 ± 4.2%; p < 0.001, and O.Th, 7.4 µm ± 2.0 vs. 5.2 ± 1.0; p < 0.05). Our results showed that the modeling-based bone formation on trabecular bone surfaces occurs even during adulthood. As FMiSs can represent histological evidence of modeling-based bone formation, understanding of this physiology in relation to bone homeostasis is crucial.

Keywords: modeling-based bone formation; forming minimodeling structures; femoral head; bone histomorphometry; femoral neck fracture; rheumatoid arthritis; hip osteoarthritis

Links

DOI: 10.3389/fendo.2018.00088

PubMed: 29615973

WoS: 000427714400001

History

Received: 2017-12-25

Accepted: 2018-02-23

Online: 2018-03-19

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Cited By (4)

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2022	Rooney AM, Dempster DW, Nieves JW, Zhou H, Bostrom MPG, Cosman F. Effects of teriparatide and loading modality on modeling-based and remodeling-based bone formation in the human femoral neck. Bone. April 2022;157:116342.
2022	Lamarche BA, Thomsen JS, Andreasen CM, Lievers WB, Andersen TL. 2D size of trabecular bone structure units (BSU) correlate more strongly with 3D architectural parameters than age in human vertebrae. Bone. July 2022;160:116399.
2020	Dempster DW, Chines A, Bostrom MP, Nieves JW, Zhou H, Chen L, Pannacciulli N, Wagman RB, Cosman F. Modeling‐based bone formation in the human femoral neck in subjects treated with denosumab. J Bone Miner Res. July 2020;35(7):1282-1288.
2023	Sano H, Whitmarsh T, Skingle L, Shimakura T, Yamamoto N, Compston JE, Takahashi HE, Poole KES. Buds of new bone formation within the femoral head of hip fracture patients coincide with zones of low osteocyte sclerostin. J Bone Miner Res. November 2023;38(11):1603-1611.