A wide range of workers is exposed to Foot-Transmitted Vibration (FTV). Exposure to this kind of vibration is associated with an increased risk of developing vibration-induced white foot. This paper presents a two-dimensional biodynamic lumped element model describing the response of the foot- ankle system to vibration. The model is composed of four segments linked together and connected to the ground by three couples of springs and dampers elements. The stiffness and damping were estimated by minimizing the difference between the modelled transmissibility and the average transmissibility taken from literature data. Five different points of the feet were taken into account, in the frequency range of 10 Hz – 100 Hz. The results showed that the model correctly describes the experimental data (maximum transmissibility error lower than 0.11 and 0.70 rad for the modulus and the phase), especially with respect to the inter-participant variability experimentally observed (in average 0.52 and 1.65 rad for the modulus and the phase). This contribution can aid in the development of materials and equipment to attenuate FTV and, consequently, to lower the risk of developing vibration-induced white foot.