Cost-effectiveness of romosozumab for the treatment of postmenopausal women with severe osteoporosis at high risk of fracture in Sweden

Söreskog, E.<sup>1</sup>; Lindberg, I.<sup>1</sup>; Kanis, J. A.<sup>2,3</sup>; Åkesson, K. E.<sup>4</sup>; Willems, D.<sup>5</sup>; Lorentzon, M.<sup>3,6,7</sup>; Ström, O.<sup>1,8</sup>; Berling, P.<sup>9</sup>; Borgström, F.<sup>1,8</sup>

Affiliations

¹Quantify Research, Stockholm, Sweden

²University of Sheffield, Sheffield, UK

³Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia

⁴Lund University, Skåne University Hospital, Malmö, Sweden

⁵UCB Pharma, Brussels, Belgium

⁶Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

⁷Geriatric Medicine Clinic, Sahlgrenska University Hospital, Mölndal, Sweden

⁸Karolinska Institutet, Stockholm, Sweden

⁹UCB Pharma, Stockholm, Sweden

Abstract and keywords

Summary: Romosozumab is a novel bone-building drug that reduces fracture risk. This health economic analysis indicates that sequential romosozumab-to-alendronate can be a cost-effective treatment option for postmenopausal women with severe osteoporosis at high risk of fracture.

Purpose: To estimate the cost-effectiveness of sequential treatment with romosozumab followed by alendronate (“romosozumab-to-alendronate”) compared with alendronate alone in patients with severe osteoporosis at high risk of fracture in Sweden.

Methods: A microsimulation model with a Markov structure was used to simulate fractures, costs, and quality-adjusted life years (QALYs), for women treated with romosozumab-to-alendronate or alendronate alone. Patients aged 74 years with a recent major osteoporotic fracture (MOF) were followed from the start of treatment until the age of 100 years or death. Treatment with romosozumab for 12 months was followed by alendronate for up to 48 months or alendronate alone with a maximum treatment duration of 60 months. The analysis had a societal perspective. Efficacy of romosozumab and alendronate were derived from phase III randomized controlled trials. Resource use and unit costs were collected from the literature. Cost-effectiveness was estimated using incremental cost-effectiveness ratio (ICER) with QALYs as effectiveness measures.

Results: The base case analysis showed that sequential romosozumab-to-alendronate treatment was associated with 0.089 additional QALYs at an additional cost of €3002 compared to alendronate alone, resulting in an ICER of €33,732. At a Swedish reference willingness-to-pay per QALY of €60,000, romosozumab-to-alendronate had a 97.9% probability of being cost-effective against alendronate alone. The results were most sensitive to time horizon, persistence assumptions, patient age, and treatment efficacy.

Conclusion: The results of this study indicate that sequential romosozumab-to-alendronate can be a cost-effective treatment option for postmenopausal women with severe osteoporosis at high risk of fracture.

Keywords: Cost-effectiveness; Economic evaluation; Imminent fracture risk; Markov-microsimulation model; Osteoporosis; Recent fracture

Links

DOI: 10.1007/s00198-020-05780-8

PubMed: 33409591

WoS: 000605492800001

History

Received: 2020-08-27

Accepted: 2020-12-04

Online: 2021-01-06

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