Multimodal evaluation of the spatiotemporal variations of periprosthetic bone properties

Fraulob, Manon; Le Cann, Sophie; Voumard, Benjamin; Yasui, Hirokazu; Yano, Keita; Vayron, Romain; Matsukawa, Mami; Zysset, Philippe; Haïat, Guillaume

Affiliations

¹MSME, CNRS UMR 8208, Univ Paris Est Creteil, Univ Gustave Eiffel, Creteil F-94010, France

²ARTORG Centre for Biomedical Engineering Research, University of Bern, Freiburgstrasse 3, Bern CH-3010, Switzerland

³Laboratory of Ultrasonic Electronics, Applied Ultrasonic Research Center, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan

⁴Universite Polytechnique Hauts de France, Laboratoire d’Automatique, de Mecanique et d’informatique Industrielles et Humaines, LAMIH UMR CNRS 8201, Valenciennes F-59300, France

Abstract and keywords

Titanium implants are widely used in dental and orthopedic surgeries. However, implant failures still occur because of a lack of implant stability. The biomechanical properties of bone tissue located around the implant need to be assessed to better understand the osseointegration phenomena and anticipate implant failure. The aim of this study was to explore the spatiotemporal variation of the microscopic elastic properties of newly formed bone tissue close to an implant. Eight coin-shaped Ti6Al4V implants were inserted into rabbit tibiae for 7 and 13 weeks using an in vivo model allowing the distinction between mature and newly formed bone in a standardized configuration. Nanoindentation and micro-Brillouin scattering measurements were carried out in similar locations to measure the indentation modulus and the wave velocity, from which relative variations of bone mass density were extracted. The indentation modulus, the wave velocity and mass density were found to be higher (1) in newly formed bone tissue located close to the implant surface, compared to mature cortical bone tissue, and (2) after longer healing time, consistently with an increased mineralization. Within the bone chamber, the spatial distribution of elastic properties was more heterogeneous for shorter healing durations. After 7 weeks of healing, bone tissue in the bone chamber close to the implant surface was 12.3% denser than bone tissue further away. Bone tissue close to the chamber edge was 16.8% denser than in its center. These results suggest a bone spreading pathway along tissue maturation, which is confirmed by histology and consistent with contact osteogenesis phenomena.

Keywords: bone; implant; nanoindentation; micro-Brillouin scattering; osseointegration

Links

DOI: 10.1115/1.4048399

PubMed: 32909597

WoS: 000589639200002

History

Received: 2020-03-26

Revised: 2020-08-03

Online: 2020-10-28

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