Discovery of bone morphogenetic proteins:​ a historical perspective

Sampath, T. Kuber; Reddi, A. Hari

Affiliations

¹perForm biologics Inc., Holliston, MA, United States of America

²Lawrence Ellison Center for Musculoskeletal Regeneration, Department of Orthopedic Surgery, School of Medicine, University of California at Davis, Sacramento, CA, United States of America

Abstract and keywords

Bone morphogenetic proteins (BMPs) were purified from demineralized bone matrix by their ability to induce new bone formation in vivo. BMPs represent a large sub-family of proteins structurally related to TGF-beta and activins. Two BMP bone graft substitutes, BMP2 (InFuse®) and BMP7 (OP1®) have been developed as products for the repair of long bone non-union fractures and lumbar spinal fusion in humans. The approval of BMP2 and BMP7 based products for use in the clinic supports that the signals responsible for bone formation at ectopic sites can form a basis as therapeutics for bone repair and regeneration. This article describes a historical perspective of the discovery BMPs.

Keywords: BMP; Bone repair; Review

Links

DOI: 10.1016/j.bone.2020.115548

PubMed: 32730937

WoS: 000572849900005

History

Received: 2020-06-24

Revised: 2020-07-6

Accepted: 2020-07-6

Online: 2020-07-27

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Cited By (1)

Year	Entry
2020	Vukicevic S, Sampath KT, Luyten FP. Editorial - "The role of bone morphogenetic proteins (BMPs) in musculoskeletal biology". Bone. December 2020;141:115622.