BMP gene delivery for skeletal tissue regeneration

Bez, Maxim; Pelled, Gadi; Gazit, Dan

Affiliations

¹Medical Corps, Israel Defense Forces, Israel

²Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA

³Skeletal Biotech Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem, Jerusalem, Israel

⁴Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA

⁵Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA

⁶Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA

⁷Department of Orthopedics, Cedars-Sinai Medical Center, Los Angeles, California, USA

Abstract and keywords

Musculoskeletal disorders are common and can be associated with significant morbidity and reduced quality of life. Current treatments for major bone loss or cartilage defects are insufficient. Bone morphogenetic proteins (BMPs) are key players in the recruitment and regeneration of damaged musculoskeletal tissues, and attempts have been made to introduce the protein to fracture sites with limited success. In the last 20 years we have seen a substantial progress in the development of various BMP gene delivery platforms for several conditions. In this review we cover the progress made using several techniques for BMP gene delivery for bone as well as cartilage regeneration, with focus on recent advances in the field of skeletal tissue engineering. Some methods have shown success in large animal models, and with the global trend of introducing gene therapies into the clinical setting, it seems that the day in which BMP gene therapy will be viable for clinical use is near.

Keywords: Gene therapy; Tissue engineering; Bone morphogenetic protein

Links

DOI: 10.1016/j.bone.2020.115449

PubMed: 32447073

WoS: 000547005800050

History

Received: 2020-03-9

Revised: 2020-05-20

Accepted: 2020-05-20

Online: 2020-05-21

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Cited By (1)

Year	Entry
2020	Vukicevic S, Sampath KT, Luyten FP. Editorial - "The role of bone morphogenetic proteins (BMPs) in musculoskeletal biology". Bone. December 2020;141:115622.