Biomechanical characteristics of human trabecular bone

Ouyang, J.; Yang, G. T.; Wu, W. Z.; Zhu, Q. A.; Zhong, S. Z.

Affiliations

¹Medical Biomechanical Laboratory of PLA, The First Military Medical University, Guangzhou, P.R. China

²Institute of Applied Mechanics, Taiyuan University of Technology, Taiyuan, P.R. China

Abstract and keywords

Objective: To evaluate the effect of strain rate (̇ε), apparent density (ρ_a) and tissue density (ρ_t) on Young's modulus (E), strength (σ_u) and ultimate strain (ε_u) on intervertebral bone from a Chinese population.

Methods: Testing was performed by uniaxial compression at five strain rates on 36 human trabecular bone specimens from three male T₁₂~L₄ vertebrae.

Results: Apparent density ranged between 0.46 and 0.71 g/cm³. Tissue density ranged between 1.02 and 1.54 g/cm³. Non-linear regression analyses using strength, Young's modulus or ultimate strain as dependent variables (Y) and strain rate and apparent density or tissue density as independent variables were performed using the following equation: Y=aρ^ḃε^c. The exponent of apparent density and strain rate to Young's modulus were 1.88 and 0.07, separately (P = 0.0007). The variation of strength was explained only by apparent density with an exponent of 1.29 (P = 0.0107). The variation of Young's modulus was explained equally by the quadratic and cubic relationship to apparent density or tissue density (P < 0.01). Ultimate strain varied independently of apparent density or tissue density and strain rate.

Relevance: An understanding of the biomechanical characteristics of human trabecular bone can help us to understand the mechanism of spine compressive fracture.

Keywords: Trabecular bone; apparent density; strain rate

Links

DOI: 10.1016/S0268-0033(97)00035-1

PubMed: 11415763

WoS: 000073330400014

History

Received: 1997-01-22

Accepted: 1997-05-06

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Cited By (15)

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2005	Williams JM, Adewunmi A, Schek RM, Flanagan CL, Krebsbach PH, Feinberg SE, Hollister SJ, Das S. Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. Biomaterials. August 2005;26(23):4817-4827.
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2020	Li Z, Wang J, Song G, Ji C, Han X. Anisotropic and strain rate-dependent mechanical properties and constitutive modeling of the cancellous bone from piglet cervical vertebrae. Comput Methods Prog Biomed. May 2020;188:105279.
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2014	Schileo E, Balistreri L, Grassi L, Cristofolini L, Taddei F. To what extent can linear finite element models of human femora predict failure under stance and fall loading configurations? J Biomech. November 7, 2014;47(14):3531-3538.
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2012	Emerson NJ. Development of Patient-Specific CT-FE Modelling of Bone Through Validation Using Porcine Femora [PhD thesis]. University of Sheffield; September 2012.
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