Bicyclists and pedestrians belong to the most endangered groups in urban traffic. The EU-funded collaborative research project PROSPECT (‘PROactive Safety for PEdestrians and CyclisTs ́) aims to significantly improve safety of those unprotected traffic participants by expanding the scope of scenarios covered by future active safety systems in passenger cars. Concepts for sensor control systems are built into three prototypes covering emergency interventions such as Autonomous Emergency Braking (AEB) as well as Autonomous Emergency Steering (AES). These systems tackle the well-known challenges of currently available systems including limited field-of-view by sensors, fuzzy path prediction, unreliable intent reaction times and slow reaction times. These highly innovative functions call for extensive validation methodologies based on already established consumer testing procedures. Since these functions are developed towards the prevention of intersection accidents in urban areas, a key aspect of the advanced testing methodology is the valid approximation of naturalistic trajectories using driving robots. Eventually, several simulator studies complemented a user acceptance and benefit analysis to evaluate the expected overall impact of the PROSPECT systems. The results achieved within the PROSPECT project are highly relevant for upcoming test protocols regarding the most critical situations with Vulnerable Road Users (VRU). With introducing the new methods in Euro NCAP (European New Car Assessment Programme) a significant increase in road safety is expected.