The objective of this study was to provide scientifically-based estimates of the societal benefits and costs of two large truck advanced driver assistance systems (ADASs):​ automatic emergency braking (AEB) and lane departure warning (LDW). For each technology, benefit-cost analyses (BCA) were performed for installing the technology on all large trucks (including retrofitting old trucks) and for equipping new large trucks only, and were performed for equipping only single-unit trucks, only combination-unit trucks, and all large trucks. Sensitivity analyses examined three cost estimates, two estimates of system efficacy, and three discount rates. Equipping trucks with LDW systems were found cost-effective under almost all scenarios examined. Results for AEB were mixed. Only the low cost estimate was cost effective for all large trucks regardless of efficacy rate .