Age-related changes in trabecular width and spacing in human iliac crest biopsies

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Mellish, R. W. E.¹; Garraha, N. J.¹; Compston, J. E.¹

Age-related changes in trabecular width and spacing in human iliac crest biopsies

Bone Miner. July 1989;6(3):331-338

©1989 Elsevier Science Publishers B.V. (Biomedical Division)

Affiliations

¹Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales, UK
Abstract and keywords

Age-related changes in trabecular width and spacing have been examined in iliac crest bone obtained from 96 normal subjects. The mean trabecular plate density and separation were calculated from values of trabecular bone volume and mean trabecular plate thickness. There was an age-related decrease in mean trabecular plate thickness with age in both sexes; this was statistically significant in males (P <0.02) but not in females. In females, there was a significant decrease in mean trabecular plate density (P < 0.001) and increase in mean trabecular plate separation (P <0.001); similar but non-significant trends were observed in the males. These results demonstrate that trabecular thinning contributes to age-related bone loss in both sexes. Loss of trabeculae also occurs in both sexes, but to a greater extent in females than in males.

Keywords: Trabecular bone; Ageing; Microanatomic structure; Trabecular width; Trabecular spacing; Bone loss
Links

DOI: 10.1016/0169-6009(89)90038-X

PubMed: 2758161

WoS: A1989AF63800008
History

Received: 1987-09-15

Accepted: 1988-12-19

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1992	Bradbeer JN, Arlott ME, Meunier PJ, Reeve J. Treatment of osteoporosis with parathyroid peptide (hPTH 1-34) and oestrogen: increase in volumetric density of iliac cancellous bone may depend on reduced trabecular spacing as well as increased thickness of packets of newly formed bone. Clin Endocrinol. September 1992;37(3):282-289.
2001	Fajardo RJ, Müller R. Three‐dimensional analysis of nonhuman primate trabecular architecture using micro‐computed tomography. Am J Phys Anthropol. 2001;115(4):327-336.
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1991	Parfitt AM, Foldes J. The ambiguity of interstitial bone thickness: a new approach to the mechanism of trabecular thinning. Bone. 1991;12(2):119-122.
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1992	Parfitt AM. Implications of architecture for the pathogenesis and prevention of vertebral fracture. Bone. 1992;13(suppl 2):S41-S47.
1995	Dempster DW, Birchman R, Xu R, Lindsay R, Shen V. Temporal changes in cancellous bone structure of rats immediately after ovariectomy. Bone. January 1995;16(1):157-161.
1995	Grote HJ, Amling M, Vogel M, Hahn M, Pösl M, Delling G. Intervertebral variation in trabecular microarchitecture throughout the normal spine in relation to age. Bone. March 1995;16(3):301-308.
2000	Day JS, Ding M, Odgaard A, Sumner DR, Hvid I, Weinans H. Parallel plate model for trabecular bone exhibits volume fraction-dependent bias. Bone. November 2000;27(5):715-720.
2009	Fajardo RJ, Cory E, Patel ND, Nazarian A, Laib A, Manoharan RK, Schmitz JE, DeSilva JM, MacLatchy LM, Snyder BD, Bouxsein ML. Specimen size and porosity can introduce error into μCT-based tissue mineral density measurements. Bone. 2009;44(1):176-184.
1990	Kimmel DB, Recker RR, Gallagher JC, Vaswani AS, Aloia JF. A comparison of iliac bone histomorphometric data in post-menopausal osteoporotic and normal subjects. Bone Miner. November 1990;11(2):217-235.
1991	Grynpas MD, Alpert B, Katz I, Lieberman I, Pritzker KPH. Subchondral bone in osteoarthritis. Calcif Tiss Int. January 1991;49(1):20-26.
1991	Mellish RWE, Ferguson‐Pell MW, Cochran GVB, Lindsay R, Dempster DW. A new manual method for assessing two‐dimensional cancellous bone structure: comparison between iliac crest and lumbar vertebra. J Bone Miner Res. July 1991;6(7):689-696.
1991	Cohen‐Solal ME, Shih M, Lundy MW, Parfitt AM. A new method for measuring cancellous bone erosion depth: application to the cellular mechanisms of bone loss in postmenopausal osteoporosis. J Bone Miner Res. December 1991;6(12):1331-1338.
1996	Han Z, Palnitkar S, Rao DS, Nelson D, Parfitt AM. Effect of ethnicity and age or menopause on the structure and geometry of iliac bone. J Bone Miner Res. December 1996;11(12):1967-1975.
2000	Oleksik A, Ott SM, Vedi S, Bravenboer N, Compston J, Lips P. Bone structure in patients with low bone mineral density with or without vertebral fractures. J Bone Miner Res. July 2000;15(7):1368-1375.
2007	Compston JE, Vedi S, Kaptoge S, Seeman E. Bone remodeling rate and remodeling balance are not co-regulated in adulthood: implications for the use of activation frequency as an index of remodeling rate. J Bone Miner Res. July 2007;22(7):1031-1036.
1998	Ladd AJC, Kinney JH, Haupt DL, Goldstein SA. Finite‐element modeling of trabecular bone: comparison with mechanical testing and determination of tissue modulus. J Orthop Res. September 1998;16(5):622-628.
1993	Dempster DW, Ferguson-Pell MW, Mellish RWE, Cochran GVB, Xie F, Fey C, Horbert W, Parisien M, Lindsay R. Relationships between bone structure in the iliac crest and bone structure and strength in the lumbar spine. Osteoporos Int. March 1993;3(2):90-96.
1994	Müller R, Hildebrand T, Rüegsegger P. Non-invasive bone biopsy: a new method to analyse and display the three-dimensional structure of trabecular bone. Phys Med Biol. January 1994;39(1):145-164.
2022	Chlebek C. Identification of Novel Cellular Pathways Involved in Bone Mechanotransduction Using Transcriptomics [PhD thesis]. Ithaca, NY: Cornell University; May 2022.
2005	Day JS. Bone Quality: The Mechanical Effects of Microarchitecture and Matrix Properties [PhD thesis]. Erasmus University Rotterdam; 2005.
2005	Buie HR. Use of Finite Element Method Modelling and Rapid Prototyping to Study the Effect of Trabecular Bone Architecture on Apparent Mechanical Properties [Master's thesis]. Queen's University; November 2005.