Head and neck responses of anthropomorphic test devices and computational human body models should be validated in different impact modes, e.g., frontal, oblique, side, and twist. The main objective of this study is to create biomechanical response targets of the head and neck of post mortem human surrogates using a controlled mini‐sled system in various impact scenarios. A mini‐sled was designed to dynamically test a post mortem human subject head‐neck complex. A six axis load cell wa s attached at the T3 level of the spine to measure the reaction loads at the upper thoracic spine for the frontal, oblique and side impacts, while T1 was attached to the load cell for the twist test. The post mortem human subject head, C3, and C5 were instrumented using accelerometers and angular rate sensors to capture head and cervical kinematics. Five post mortem human subjects were tested in frontal (5), oblique (2), side (2), and twist (1) scenarios at a nominal mini‐sled velocity of 14 km/h for frontal, side, and oblique impacts and 1,800 deg/s for the twist scenario. Biomechanical responses of the head and lower neck were measured in various impact conditions. Biomechanical targets were created for future biofidelity evaluation for anthropomorphic test devices and computational human body models.