The body regional injury information from the head, thorax, abdomen, upper and lower extremities of vehicle occupant due to the restraints and interior parts were extracted from 2009-2012 NASS/CDS data base. For those cases with high occurrence frequency, detailed and comprehensive data analysis was performed to find significances between the accident, occupant, vehicle, and injury data. A numerical frontal impact sled model with Hybrid III dummy and GHBMC human body model is constructed to simulate and identify those injury risks at NASS/CDS. Among the 5,734 body regional injuries from frontal crash accidents, lower extremity (27.8%), upper extremity (21.3%), thorax (15.1%), face (10.9%), spine (8,7%), head (7.3%), and abdomen (6.9%) were found in order of frequent occurrence. The main injury sources of the head were windshield, side structure, and steering wheel. For thorax and abdomen, they were seat belt and steering wheel. Instrument panel was for the lower extremity. Body regional injury patterns for head were concussion and contusion. For thorax, they were vessel laceration and lung contusion. For abdomen, laceration and contusion of organs were major injury patterns. Bone fracture and ligament rupture were found at the lower extremity. Steering wheel and seat positions were main factors affect head and thorax injury risks. From the sled impact simulation, high injury risks of the head and thorax were assessed respectively at conditions of steering column tilt down and rear most seat positions, which correlated well with the findings at NASS/CDS data analysis.