Biomechanics of brain injury:​ looking to the future

Meaney, David F.

Affiliations

¹Departments of Bioengineering and Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA

Abstract

In this chapter, we review the state of the field in understanding how the cellular components of the brain and spinal cord respond to the biomechanical loading that occurs at the moment of traumatic injury. Several other recent reviews can be collected and reviewed in their own right for this purpose (Kumaria A, Tolias CM, Br J Neurosurg 22(2):200–206, 2008; Morrison B 3rd, Elkin BS, Dolle JP, Yarmush ML, Annu Rev Biomed Eng 13:91–126, 2011; Chen YC, Smith DH, Meaney DF, J Neurotrauma 26(6):861–876, 2009; LaPlaca MC, Simon CM, Prado GR, Cullen DK, Prog Brain Res 161:13–26, 2007). Rather, we intend to provide a broad overview of the basic principles that led to our current understanding of how cells in the nervous system respond to mechanical force. We also point out critical emerging areas in this discipline as we move from molecules, genes, and cells to circuit, behavior and degenerative disease. Our holistic objective is bringing a mechanistic understanding of how mechanotransmission in the CNS can shape the neurobehavioral response of the organism after traumatic CNS injury.

Links

DOI: 10.1007/978-1-4939-1732-7_10

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Cited By (1)

Year	Entry
2020	Zhou R. Development of Rat Head Finite Element Model and Tissue Level Biomechanical Threshold for Traumatic Axonal Injury [PhD thesis]. Detroit, MI: Wayne State University; May 2020.