Nanoporous material functionalized liquid (NMFL) is now one of the candidates of advanced energy mitigation material, as supported by recent studies. In this study, quasi‐static compression experiments and finite element (FE) simulations are conducted to investigate the energy absorption enhancement effect of NMFL as a filler in a thin‐walled stainless steel tube. The influence of infiltration pressure (Pin), and the interaction effect between NMFL filler and tube wall are comprehensively explored. Results show that the filling with NMFL can enhance the energy absorption capacity of thin‐walled tubes under axial compression by 25% at the present configuration, which comes from the nano‐scale infiltration of NMFL by converting mechanical energy into excessive interfacial energy, and its interaction effect with thin‐walled buckling. Pin has a significant impact on the energy absorption characteristics and buckling behavior.