Users of two-wheeled vehicles (cyclists, moped and motorcycle riders) are, along with pedestrians, the most vulnerable category of road users in an injury accident. In France, contrary to pedestrians, they have not derived any great benefit from recent improvements in safety.

Over the past ten years, the use of two-wheelers in France has greatly declined. This is due essentially to the diminution in the use of the moped (not needing a licence). The population groups representing the highest risk differ according to the category of two-wheeler concerned:​ children and elderly people for bicycles, teenagers for mopeds and young adults (males) for motorcycles. The characteristics of accidents are also category-related, but most of the two-wheeler accidents involve a car. For these accidents the most frequent individual manoeuvre carried out by the two-wheeler driver is that of driving without changing direction. The greatest proportion of two-wheeler accidents therefore originates in a manoeuvre undertaken by a car driver.

Improving two-wheeler visibility is a major priority. But this also means that two-wheeler safety is largely subject to the skill and vigilance of car drivers Car manufacturers should give better greater consideration to this problem. This is necessary, but technical solutions (for improving the visibility of two-wheelers in the traffic for car drivers) are nevertherless not easy to find and are in themselves insufficent. Car drivers, the automobile industry and road authorities must not consider road safety only from the point of view of car occupants.