The article commences with a summary of accidents involving commercial vehicles. A discription of the major points is followed by the results from the analyses of 400 accidents involving injury or deaths to the vehicle passenger. The injured or killed commercial vehicle passengers are of particular significance because the commercial vehicle is also the workplace at the same time In conclusion, measures to lower the accident risk to commercial vehicle passengers are discussed while taking the results of crash tests into consideration. Funher aspects are the hazards to other road-users. Safety measures are also discussed to this end. Entirely observations indicate possible additional applications for existing special safety installations through the general protective functions. The closing discussion considers the possible benefits and defines the needs for further research.