This paper focuses on tire aging and tire failures due to increased chronological tire age, miles driven, and harsher environmental conditions. Fundamental material failure mechanism is presented first to illustrate why tires are aging faster under higher loads or temperatures. Then Kaplan-Meier curves and Logrank tests are used to compare various risk factors that may lead to tire aging. Similarly, Weibull analysis is used to predict the tire failure probability against tire age or mileage. Finally, Cox proportional hazard model is utilized to explore the tire aging relative risk with statistical significances. It is found that greater chronological tire age, higher mileage, initial tire loads, and manufacturing characteristics or tire types all contribute to tire aging or failures.