The spatio-temporal arrangement of different tissues during bone healing as a result of simple mechanobiological rules

Vetter, A.; Witt, F.; Sander, O.; Duda, G. N.; Weinkamer, R.

Affiliations

¹Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14424 Potsdam, Germany

²Julius Wolff Institute and Center for Musculoskeletal Surgery, Charité-Universitätsmedizin, Augustenburger Platz 1, 13353 Berlin, Germany

³Department of Mathematics and Computer Science, Freie Universität Berlin, Arnimallee 6, 14195 Berlin, Germany

Keywords

Keywords: Bone healing; Computer simulation; Mechanobiology; Tissue differentiation; Tissue pattern; In silico

Links

DOI: 10.1007/s10237-011-0299-x

PubMed: 21431883

WoS: 000300230600011

Cited Works (11)

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1998	Carter DR, Beaupré GS, Giori NJ, Helms JA. Mechanobiology of skeletal regeneration. Clin Orthop Relat Res. October 1998;355(suppl):S41-S55.
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2009	Colnot C. Skeletal cell fate decisions within periosteum and bone marrow during bone regeneration. J Bone Miner Res. February 2009;24(2):274-282.
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1997	Prendergast PJ, Huiskes R, Søballe K. Biophysical stimuli on cells during tissue differentiation at implant interfaces. J Biomech. June 1997;30(6):539-548.
2006	Isaksson H, Wilson W, van Donkelaar CC, Huiskes R, Ito K. Comparison of biophysical stimuli for mechano-regulation of tissue differentiation during fracture healing. J Biomech. 2006;39(8):1507-1516.

Cited By (3)

Year	Entry
2013	Moore SR. Bridging Mechanics & Biology to Understand the Periosteum's Role in Bone Regeneration: Towards a Parametric Approach to Engineering Replacement Periosteum [PhD thesis]. Cleveland, OH: Case Western Reserve University; August 2013.
2019	Tourolle D. A Micro-Scale Multiphysics Framework for Fracture Healing and Bone Remodelling [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2019.
2019	Ghiasi MS. Mechanobiological Modeling on Bone Fracture Healing [PhD thesis]. Northeastern University; December 2019.