Progress on tissue-level, functional tolerance criteria and material properties of the living brain with anatomical resolution

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Morrison, III, B.¹; Yu, Z.¹; Elkin, B.¹

Progress on tissue-level, functional tolerance criteria and material properties of the living brain with anatomical resolution

Proceedings of the 2009 International IRCOBI Conference on the Biomechanics of Impact

Affiliations

¹Department of Biomedical Engineering, Columbia University, New York, USA
Abstract and keywords

Determining failure limits for biological tissues is necessary for predicting the injury potential of a loading scenario. For brain tissue, cell death and changes in electrophysiological function are more meaningful than mechanical failure criteria. Interim data is presented on a functional tolerance criterion for the hippocampus. In addition, material properties of the hippocampus were measured with the atomic force microscope. The CA1 subfield was significantly stiffer than the rest of the hippocampus. Both the tolerance criterion and material properties can be incorporated into computer models to increase their biofidelity and extend their capabilities to predict biological outcomes.

Keywords: Biomechanics; Brain; Injury Criteria; Soft Tissues

Cited Works (20)

Year	Entry
2006	Cater HL, Sundstrom LE, Morrison B III. Temporal development of hippocampal cell death is dependent on tissue strain but not strain rate. J Biomech. 2006;39(16):2810-2818.
2001	Darvish KK, Crandall JR. Nonlinear viscoelastic effects in oscillatory shear deformation of brain tissue. Med Eng Phys. 2001;23(9):633-645.
2004	Nicolle S, Lounis M, Willinger R. Shear properties of brain tissue over a frequency range relevant for automotive impact situations: new experimental results. Stapp Car Crash J. 2004;48:239-258. SAE 2004-22-0011.
1997	Smith DH, Chen X-H, Xu B-N, McIntosh TK, Gennarelli TA, Meaney DF. Characterization of diffuse axonal pathology and selective hippocampal damage following inertial brain trauma in the pig. J Neuropathol & Exp Neurol. July 1997;56(7):822-834.
2003	Takhounts EG, Crandall JR, Darvish K. On the importance of nonlinearity of brain tissue under large deformations. Stapp Car Crash J. 2003;47:79-92. SAE 2003-22-0005.
1998	Arbogast KB, Margulies SS. Material characterization of the brainstem from oscillatory shear tests. J Biomech. September 1998;31(9):801-807.
2007	Elkin BS, Morrison B. Region-specific tolerance criteria for the living brain. Stapp Car Crash J. 2007;51:127-138. SAE 2007-22-0005.
2003	Gefen A, Gefen N, Zhu Q, Raghupathi R, Margulies SS. Age-dependent changes in material properties of the brain and braincase of the rat. J Neurotrauma. November 2003;20(11):1163-1177.
1965	Sneddon IN. The relation between load and penetration in the axisymmetric Boussinesq problem for a punch of arbitrary profile. Int J Eng Sci. May 1965;3(1):47-57.
1972	Demiray H. A note on the elasticity of soft biological tissues. J Biomech. May 1972;5(3):309-311.
2001	Bain AC, Raghupathi R, Meaney DF. Dynamic stretch correlates to both morphological abnormalities and electrophysiological impairment in a model of traumatic axonal injury. J Neurotrauma. May 2001;18(5):499-511.
2007	Elkin BS, Azeloglu EU, Costa KD, Morrison B III. Mechanical heterogeneity of the rat hippocampus measured by atomic force microscope indentation. J Neurotrauma. May 2007;24(5):812-822.
2001	Zhang L, Yang KH, Dwarampudi R, Omori K, Li T, Chang K, Hardy WN, Khalil TB, King AI. Recent advances in brain injury research: a new human head model development and validation. Stapp Car Crash J. 2001;45:369-394. SAE 2001-22-0017.
2002	Prange MT, Margulies SS. Regional, directional, and age-dependent properties of the brain undergoing large deformation. J Biomech Eng. 2002;124(2):244-252.
2003	Takhounts EG, Eppinger RH, Campbell JQ, Tannous RE, Power ED, Shook LS. On the development of the SIMon finite element head model. Stapp Car Crash J. 2003;47:107-133. SAE 2003-22-0007.
2003	Morrison B III, Cater HL, Wang CC-B, Thomas FC, Hung CT, Ateshian GA, Sundstrom LE. A tissue level tolerance criterion for living brain developed with an in vitro model of traumatic mechanical loading. Stapp Car Crash J. 2003;47:93-105. SAE 2003-22-0006.
2006	Morrison B III, Cater HL, Benham CD, Sundstrom LE. An in vitro model of traumatic brain injury utilising two-dimensional stretch of organotypic hippocampal slice cultures. J Neurosci Meth. 2006;150(2):192-201.
2003	Gu WY, Yao H, Huang CY, Cheung HS. New insight into deformation-dependent hydraulic permeability of gels and cartilage, and dynamic behavior of agarose gels in confined compression. J Biomech. April 2003;36(4):593-598.
2008	Takhounts EG, Ridella SA, Hasija V, Tannous RE, Campbell JQ, Malone D, Danelson K, Stitzel J, Rowson S, Duma S. Investigation of traumatic brain injuries using the next generation of Simulated Injury Monitor (SIMon) finite element head model. Stapp Car Crash J. 2008;52:1-31. SAE 2008-22-0001.
2006	Hrapko M, van Dommelen J, Peters GWM, Wismans JSHM. The mechanical behaviour of brain tissue: large strain response and constitutive modelling. Biorheology. 2006;43(5):623-636.

Cited By (2)

Year	Entry
2013	Mackay M. IRCOBI: past, present and future. In: Proceedings of the 2013 International IRCOBI Conference on the Biomechanics of Injury. September 11-13, 2013; Gothenburg, Sweden.i-ix.
2014	Patton DA. The Biomechanical Determinants of Sports-Related Concussion: Finite Element Simulations of Unhelmeted Head Impacts to Evaluate Kinematic and Tissue-Level Predictors of Injury and Investigate the Design Implications for Soft-Shell Headgear [PhD thesis]. University of New South Wales; March 2014.