The purpose of this paper is to determine the static and dynamic rupture pressures of 20 human and 20 porcine eyes. This study found the static test results show an average rupture pressure for porcine eyes of 1.00 ± 0.18 MPa while the average rupture pressure for human eyes was 0.36 ± 0.20 MPa. For dynamic loading, the average porcine rupture pressure was 1.64 ± 0.32 MPa, and the average rupture pressure for human eyes was 0.91 ± 0.29 MPa. Significant differences are found between average rupture pressures from all four groups of tests (p = 0.01). A risk function has been developed and predicts a 50% risk of globe rupture at 1.02 MPa, 1.66 MPa, 0.35 MPa, and 0.90 MPa internal pressure for porcine static, porcine dynamic, human static, and human dynamic loading conditions, respectively.