Repair and tissue engineering techniques for articular cartilage

Makris, Eleftherios A.<sup>1</sup>; Gomoll, Andreas H.<sup>2</sup>; Malizos, Konstantinos N.<sup>3</sup>; Hu, Jerry C.<sup>1</sup>; Athanasiou, Kyriacos A.<sup>3</sup>

Affiliations

¹Department of Biomedical Engineering, University of California Davis, One Shields Avenue, Davis, 95616, CA, USA

²Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, 02115, MA, USA

³Department of Orthopaedic Surgery and Musculoskeletal Trauma, University of Thessaly, Biopolis, 41110, Larisa, Greece

³Department of Orthopaedic Surgery, University of California Davis, One Shields Avenue, Davis, 95616, CA, USA

Abstract

Chondral and osteochondral lesions due to injury or other pathology commonly result in the development of osteoarthritis, eventually leading to progressive total joint destruction. Although current progress suggests that biologic agents can delay the advancement of deterioration, such drugs are incapable of promoting tissue restoration. The limited ability of articular cartilage to regenerate renders joint arthroplasty an unavoidable surgical intervention. This Review describes current, widely used clinical repair techniques for resurfacing articular cartilage defects; short-term and long-term clinical outcomes of these techniques are discussed. Also reviewed is a developmental pipeline of acellular and cellular regenerative products and techniques that could revolutionize joint care over the next decade by promoting the development of functional articular cartilage. Acellular products typically consist of collagen or hyaluronic-acid-based materials, whereas cellular techniques use either primary cells or stem cells, with or without scaffolds. Central to these efforts is the prominent role that tissue engineering has in translating biological technology into clinical products; therefore, concomitant regulatory processes are also discussed.

Links

DOI: 10.1038/nrrheum.2014.157

PubMed: 25247412

WoS: 000346926500006

History

Online: 2014-09-23

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Year	Entry
2023	Chariyev-Prinz F, Szojka A, Neto N, Burdis R, Monaghan MG, Kelly DJ. An assessment of the response of human MSCs to hydrostatic pressure in environments supportive of differential chondrogenesis. J Biomech. June 2023;154:111590.
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2017	Huwe LW. Functional Articular Cartilage Engineering for Regenerating the Patellofemoral and Temporomandibular Joints [PhD thesis]. Davis, University of California; 2017.
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