Osteoarthritis:​ a disease of the joint as an organ

Loeser, Richard F.<sup>1</sup>; Goldring, Steven R.<sup>2</sup>; Scanzello, Carla R.<sup>3</sup>; Goldring, Mary B.<sup>2</sup>

Year	Entry
2020	Shiraishi K, Chiba K, Okazaki N, Yokota K, Nakazoe Y, Kidera K, Yonekura A, Tomita M, Osaki M. In vivo analysis of subchondral trabecular bone in patients with osteoarthritis of the knee using second-generation high-resolution peripheral quantitative computed tomography (HR-pQCT). Bone. March 2020;132:115155.
2020	Muschter D, Fleischhauer L, Taheri S, Schilling AF, Clausen-Schaumann H, Grässel S. Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model. Bone. April 2020;133:115181.
2021	Abeynayake N, Arthur A, Gronthos S. Crosstalk between skeletal and neural tissues is critical for skeletal health. Bone. January 2021;142:115645.
2021	Klose-Jensen R, Hartlev LB, Thomsen JS, Nyengaard JR, Boel LWT, Laursen M, Laurberg TB, Stengaard-Pedersen K, Hauge E-M. Calcified cartilage in patients with osteoarthritis of the hip compared to that of healthy subjects: a design-based histological study. Bone. February 2021;143:115660.
2021	Chiu Y-S, Bamodu OA, Fong I-H, Lee W-H, Lin C-C, Lu C-H, Yeh C-T. The JAK inhibitor tofacitinib inhibits structural damage in osteoarthritis by modulating JAK1/TNF-alpha/IL-6 signaling through Mir-149-5p. Bone. October 2021;151:116024.
2022	Liu L, Bai H, Jiao G, Wang X, Zhang Z, Song X, Ma T, Li T, Gao L. CF101 alleviates OA progression and inhibits the inflammatory process via the AMP/ATP/AMPK/mTOR axis. Bone. February 2022;155:116264.
2020	Shere C, Fuggle NR, Edward MH, Parsons CM, Jameson KA, Cooper C, Dennison EM, Ward KA. Jumping joints: the complex relationship between osteoarthritis and jumping mechanography. Calcif Tiss Int. February 2020;106(2):115-123.
2017	Rodriguez-Vila B, Sánchez-González P, Oropesa I, Gomez EJ, Pierce DM. Automated hexahedral meshing of knee cartilage structures: application to data from the osteoarthritis initiative. Comput Methods Biomech Biomed Eng. 2017;20(14):1543-1553.
2014	Sanchez-Adams J, Leddy HA, McNulty AL, O’Conor CJ, Guilak F. The mechanobiology of articular cartilage: bearing the burden of osteoarthritis. Curr Rheumatol Rep. October 2014;16(10):451.
2021	Li K, Yang P, Zhang Y, Zhang Y, Cao H, Liu P, Huang B, Xu S, Lai P, Lei G, Liu J, Tang Y, Bai X, Zou Z. DEPTOR prevents osteoarthritis development via interplay with TRC8 to reduce endoplasmic reticulum stress in chondrocytes. J Bone Miner Res. February 2021;36(2):400-411.
2022	Rux D, Helbig K, Han B, Cortese C, Koyama E, Han L, Pacifici M. Primary cilia direct murine articular cartilage tidemark patterning through hedgehog signaling and ambulatory load. J Bone Miner Res. June 2022;37(6):1097-1116.
2022	Turlo AJ, McDermott BT, Barr ED, Riggs CM, Boyde A, Pinchbeck GL, Clegg PD. Gene expression analysis of subchondral bone, cartilage, and synovium in naturally occurring equine palmar/plantar osteochondral disease. J Orthop Res. March 2022;40(3):595-603.
2022	Karim A, Bajbouj K, Qaisar R, Hall AC, Hamad M. The role of disrupted iron homeostasis in the development and progression of arthropathy. J Orthop Res. June 2022;40(6):1243-1250.
2022	Chan KM, Yeater TD, Allen KD. Age alters gait compensations following meniscal injury in male rats. J Orthop Res. December 2022;40(12):2780-2791.
2023	Sun C, Cao C, Zhao T, Guo H, Fleming BC, Owens B, Beveridge J, McAllister S, Wei L. A2M inhibits inflammatory mediators of chondrocytes by blocking IL-1β/NF-κB pathway. J Orthop Res. January 2023;41(1):241-248.
2023	Zhang J, Nishida Y, Koike H, Ito K, Zhuo L, Nishida K, Kimata K, Ikuta K, Sakai T, Urakawa H, Seki T, Imagama S. Hyaluronan in articular cartilage: analysis of hip osteoarthritis and osteonecrosis of femoral head. J Orthop Res. February 2023;41(2):307-315.
2023	Hosokawa H, Akagi R, Watanabe S, Horii M, Shinohara M, Mikami Y, Toguchi K, Kimura S, Yamaguchi S, Ohtori S, Sasho T. Nuclear receptor subfamily 1 group D member 1 in the pathology of obesity-induced osteoarthritis progression. J Orthop Res. May 2023;41(5):930-941.
2023	Grote CW, Mackay MJ, Lu Q, Liu X, Meyer AR, Wang J. A whole-joint histopathologic grading system for murine knee osteoarthritis. J Orthop Res. July 2023;41(7):1407-1418.
2023	Rydén M, Lindblom K, Yifter-Lindgren A, Turkiewicz A, Aspberg A, Tillgren V, Englund M, Önnerfjord P. A human meniscus explant model for studying early events in osteoarthritis development by proteomics. J Orthop Res. December 2023;41(12):2765-2778.
2024	Cummings J, Gao K, Chen V, Morales Martinez A, Iriondo C, Caliva F, Majumdar S, Pedoia V. The knee connectome: a novel tool for studying spatiotemporal change in cartilage thickness. J Orthop Res. January 2024;42(1):43-53.
2020	Ryan MK, Oliviero S, Costa MC, Wilkinson JM, Dall’Ara E. Heterogeneous strain distribution in the subchondral bone of human osteoarthritic femoral heads, measured with digital volume correlation. Materials. 2020;13(20):4619.
2018	Wallace C. Effects of Glucocorticoids on Chondrocytes and Cartilage [Master's thesis]. Boston University; 2018.
2020	Barthold JE. Development of Extracellular Matrix Based Biomaterials for Articular Cartilage Repair [PhD thesis]. University of Colorado; 2020.
2017	Silverstein AM. Development of Biofidelic Culture Models of Osteoarthritis [PhD thesis]. Columbia University; 2017.
2020	Stefani RM. Role of the Synovial Membrane in Osteoarthritis Pathogenesis and Cartilage Repair [PhD thesis]. Columbia University; 2020.
2021	Hu YJ. Microstructure and Biomechanics of the Subchondral Bone in the Development of Knee Osteoarthritis [PhD thesis]. Columbia University; 2021.
2020	Feeney E. Synovial Fluid Lubrication in Disease: Characterization, Mechanisms, and Therapy [PhD thesis]. Ithaca, NY: Cornell University; May 2020.
2020	Gao T. Non-Destructive Spatial Mapping of Articular Cartilage Degradation Using Confocal Raman Microscopy [Master's thesis]. Ithaca, NY: Cornell University; August 2020.
2019	Chery DR. Biomechanics of the Pericellular Matrix: Roles in Cartilage Development and Osteoarthritis [PhD thesis]. Drexel University; January 2019.
2020	Han B. Decorin Regulates the Structure and Biomechanical Functions of Articular Cartilage Extracellular Matrix in Health and Disease [PhD thesis]. Drexel University; October 2020.
2016	Thakore PI. Targeted Gene Repression Technologies for Regenerative Medicine, Genomics, and Gene Therapy [PhD thesis]. Duke University; 2016.
2018	Huynh NPT. Bioinformatics and Molecular Approaches for the Development of Biological Artificial Cartilage [PhD thesis]. Duke University; 2018.
2019	Cutcliffe HC. In Vivo Mechanical Metrics for the Quantitative Assessment of Cartilage Health [PhD thesis]. Duke University; 2019.
2016	Müller M. Material Development for the 3D Printing of Osteochondral Grafts [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2016.
2017	Öztürk E. Biomimicking Cartilage: Engineering the Matrix, Molecular Pathways and Oxygen Sensing of Chondrocytes [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2017.
2018	Formica FA. From Electrospinning to Protein Engineering: Novel Approaches for Cartilage Repair [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2018.
2014	Thote T. Evaluation of Therapeutics Strategies for Osteoarthritis Using Contrast Based CT Imaging Atlanta, GA: Georgia Institute of Technology; August 2014.
2020	Mancipe Castro LM. Articular Cartilage- and Synoviocyte-Binding Small Molecule Drug Delivery System for the Intra-Articular Treatment of Osteoarthritis [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2020.
2021	McKinney JM Jr. Identification of Cellular Attributes That Relate to the Therapeutic Efficacy of Mesenchymal Stromal Cells for Treatment of Osteoarthritis [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2021.
2019	Ilas DC. The Role of Mesenchymal Stem Cells and Osteocytes in Subchondral Bone Changes in Hip Osteoarthritis [PhD thesis]. University of Leeds; May 2019.
2013	Moeini M. Solute Transport in Articular Cartilage: Toward Applications of Diffusion, Partitioning and Adsorption for Tissue Functional Assessment [PhD thesis]. McGill University; August 2013.
2020	Krishnan Y. Intra/extracellular Multi-Drug Delivery for Osteoarthritis [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2020.
2018	Carlson AK. Characterization of Metabolic Changes in Osteoarthritis Using Global Metabolomic Profiling [PhD thesis]. Bozeman, MT: Montana State University; July 2018.
2022	Gupta SD. Mineralized Tissues At the Osteochondral Junction in Healthy and Osteoarthritic Joints: Advanced Microimaging and Mechanical Studies [PhD thesis]. University of Oulu; 2022.
2018	Ghazi Zadeh L. Freeze-Dried Chitosan Platelet-Rich Plasma Mixtures for Knee Meniscus Repair [PhD thesis]. École polytechnique de Montréal; December 2018.
2021	Pahoff S. Fibre-Reinforced Hydrogels for Functional Cartilage Tissue Engineering [PhD thesis]. Queensland University of Technology; 2021.
2021	Ishihara S. Temporal Characteristics of Pain-Related Behaviors in a Slowly Progressive Murine Osteoarthritis Model [PhD thesis]. Rush University; 2021.
2012	Blazek K. How Obesity and Aging Interact to Create Increased Risk of Osteoarthritis and Disability [PhD thesis]. Stanford University; November 2012.
2013	Nishimuta JF. Degradation of Cartilage and Meniscus Tissues: An in Vitro Investigation in Osteoarthritis Development [PhD thesis]. Stanford University; March 2013.
2018	Baylon EG. Isn’t it Swell? The Effect of Osmotic Swelling on Articular Cartilage and Meniscal Fibrocartilage Mechanics and Diagnostic Approaches [PhD thesis]. Stanford University; March 2018.
2019	Black MS. Quantitative Imaging of Cartilage and Meniscus for Detection of Early Osteoarthritic Degeneration [PhD thesis]. Stanford University; November 2019.
2021	Watkins LE. Imaging Strategies for Quantitative, Whole-Joint Assessment of Structure and Function Related to Knee Osteoarthritis [PhD thesis]. Stanford University; June 2021.
2014	Ludwig TE. Cartilage Boundary Lubrication and Rheology of Proteoglycan 4 + Hyaluronan Solutions and Synovial Fluid [PhD thesis]. Calgary, AB: University of Calgary; June 2014.
2017	Bhatla JL. Differences in Bone and Cartilage Between Women With Anterior Cruciate Ligament Tears and Healthy Controls [Master's thesis]. Calgary, AB: University of Calgary; July 2017.
2017	Collins KH-M. Diet-Induced Obesity and Musculoskeletal Health: Studies in a Rat Model [PhD thesis]. Calgary, AB: University of Calgary; August 2017.
2019	Kroker AM. The Progression of Bone Microarchitecture Changes Following an Acute Knee Injury in Young Adults [PhD thesis]. Calgary, AB: University of Calgary; March 2019.
2019	Rios JL. Exercise and Dietary Interventions in a Rat Model of Metabolic Knee Osteoarthritis [PhD thesis]. Calgary, AB: University of Calgary; September 2019.
2023	Kaketsis D. Investigating Bone Remodelling in Knee Osteoarthritis Using HR-PQCT Imaging [Master's thesis]. Calgary, AB: University of Calgary; May 2023.
2018	Jafari S. Biomechanics of Articular Cartilage: Osteoarthritis and Tissue Engineering [PhD thesis]. San Diego (UCSD), University of California; 2018.
2018	Graham B. Novel Approaches to Determine the Role of Diffusive and Convective Transport Environments in Articular Cartilage Function [PhD thesis]. University of Delaware; 2018.
2019	David MA. Local, Intra-Articular Delivery of Zoledronic Acid as a Disease-Modifying Therapeutic for Post-Traumatic Osteoarthritis [PhD thesis]. University of Delaware; 2019.
2019	Lv M. Statin for the Prevention of Osteoarthritis: A Clinical Cohort Study and Its Cellular Mechanisms [PhD thesis]. University of Delaware; 2019.
2021	McDonough RC. Controlled Calcium Activation Via Chemogenetic Signaling Platforms for Tissue Engineering of Articular Cartilage [PhD thesis]. University of Delaware; 2021.
2017	Jacobs BY. Pathologic Gait in Osteoarthritis Models: Characterization and Treatment [PhD thesis]. University of Florida; December 2017.
2017	Lakes EH. Advancing Methods for Multiscale Mechanics in Orthopaedic Research [PhD thesis]. University of Florida; December 2017.
2022	St. Amant J. Interplay Between Integrin Alpha 1 Beta 1 and Transforming Growth Factor Beta Receptor II in the Development of Spontaneous Osteoarthritis in the Mouse Knee [Master's thesis]. University of Guelph; September 2022.
2019	Sperry MM. Multi-Scale Brain Responses in the Development of Persistent Osteoarthritic Temporomandibular Pain [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2019.
2020	Cavanagh J. Navigation and Patient Specific Instrumentation in Shoulder Arthroplasty [Master's thesis]. University of Western Ontario; 2020.
2020	Walsh SK. Effects of Age and Mechanical Loading on Articular Cartilage Metabolism and Corresponding Consequences for Tissue Health [PhD thesis]. University of Wisconsin – Madison; 2020.
2020	Ross A. Tissue Engineering of Induced Pluripotent Stem Cells for the Development of Novel Treatment Strategies for Osteoarthritis [PhD thesis]. St. Louis, MO: Washington University in St. Louis; May 2020.
2021	Katz D. Understanding and Improving Adult Stem Cells for Cartilage Tissue Engineering [PhD thesis]. St. Louis, MO: Washington University in St. Louis; August 2021.

Year	Entry
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