Porous scaffold design for tissue engineering

wbldb

Hollister, Scott J.¹

Porous scaffold design for tissue engineering

Nat Mater. July 2005;4(7):518-524

©2005 Nature Publishing Group

Affiliations

¹Scaffold Tissue Engineering Group, Departments of Biomedical Engineering, Surgery and Mechnical Engineering, 1107 Gerstacker Building, 2200 Bonisteel Boulevard, The University of Michigan, Ann Arbor, Michigan 41809, USA
Abstract

A paradigm shift is taking place in medicine from using synthetic implants and tissue grafts to a tissue engineering approach that uses degradable porous material scaffolds integrated with biological cells or molecules to regenerate tissues. This new paradigm requires scaffolds that balance temporary mechanical function with mass transport to aid biological delivery and tissue regeneration. Little is known quantitatively about this balance as early scaffolds were not fabricated with precise porous architecture. Recent advances in both computational topology design (CTD) and solid free-form fabrication (SFF) have made it possible to create scaffolds with controlled architecture. This paper reviews the integration of CTD with SFF to build designer tissue-engineering scaffolds. It also details the mechanical properties and tissue regeneration achieved using designer scaffolds. Finally, future directions are suggested for using designer scaffolds with in vivo experimentation to optimize tissue-engineering treatments, and coupling designer scaffolds with cell printing to create designer material/biofactor hybrids.
Links

DOI: 10.1038/nmat1421

PubMed: 16003400

WoS: 000230190900013

Cited Works (8)

Year	Entry
2005	Williams JM, Adewunmi A, Schek RM, Flanagan CL, Krebsbach PH, Feinberg SE, Hollister SJ, Das S. Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. Biomaterials. August 2005;26(23):4817-4827.
2002	Zein I, Hutmacher DW, Tan KC, Teoh SH. Fused deposition modeling of novel scaffold architectures for tissue engineering applications. Biomaterials. February 15, 2002;23(4):1169-1185.
2003	Sachlos E, Czernuszka JT. Making tissue engineering scaffolds work: review on the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur Cell Mater. 2003;5:29-40.
2002	Yang S, Leong K-F, Du Z, Chua C-K. The design of scaffolds for use in tissue engineering, II: rapid prototyping techniques. Tissue Eng. February 2002;8(1):1-11.
1994	Goulet RW, Goldstein SA, Ciarelli MJ, Kuhn JL, Brown MB, Feldkamp LA. The relationship between the structural and orthogonal compressive properties of trabecular bone. J Biomech. April 1994;27(4):375-389.
2003	Taboas JM, Maddox RD, Krebsbach PH, Hollister SJ. Indirect solid free form fab.rication of local and global porous, biomimetic and composite 3d polymer-ceramic scaffolds. Biomaterials. January 2003;24(1):181-194.
1993	Langer R, Vacanti JP. Tissue engineering. Science. May 14, 1993;260(5110):920-926.
2001	Hutmacher DW, Schantz T, Zein I, Ng KW, Teoh SH, Tan KC. Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. J Biomed Mater Res. May 2001;55(2):203-216.

Cited By (34)

Year	Entry
2019	Colabella L, Cisilino AP, Fachinotti V, Kowalczyk P. Multiscale design of elastic solids with biomimetic cancellous bone cellular microstructures. Struct Multidiscip Optim. August 2019;60(2):639-661.
2020	Amini M, Reisinger A, Pahr DH. Influence of processing parameters on mechanical properties of a 3D-printed trabecular bone microstructure. J Biomed Mater Res. January 2020;B108(1):38-47.
2022	Guilak F, Estes BT, Moutos FT. Functional tissue engineering of articular cartilage for biological joint resurfacing: the 2021 Elizabeth Winston Lanier Kappa Delta Award. J Orthop Res. August 2022;40(8):1721-1734.
2019	Bian T, Zhao K, Meng Q, Tang Y, Jiao H, Luo J. The construction and performance of multi-level hierarchical hydroxyapatite (HA)/collagen composite implant based on biomimetic bone Haversian motif. Mater Des. January 15, 2019;162:60-69.
2007	Moutos FT, Freed LE, Guilak F. A biomimetic three-dimensional woven composite scaffold for functional tissue engineering of cartilage. Nat Mater. February 2007;6(2):162-167.
2015	Wegst UGK, Bai H, Saiz E, Tomsia AP, Ritchie RO. Bioinspired structural materials. Nat Mater. January 2015;14(1):23-36.
2012	Strange DGT. Mechanics of Biomimetic Materials for Tissue Engineering of the Intervertebral Disc [PhD thesis]. Cambridge, UK: University of Cambridge; December 2012.
2009	Moutos FT. Biomimetic Composite Scaffolds for the Functional Tissue Engineering of Articular Cartilage [PhD thesis]. Duke University; 2009.
2014	Wüst S. 3D Bioprinting of Multicellular Skeletal Tissues [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2014.
2015	Nimeskern LG. Functional Characterization of Auricular Cartilage in Tissue Engineering and Regenerative Medicine [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2015.
2007	Phillips JE. Runx2-Genetically Engineered Dermal Fibroblasts for Orthopaedic Tissue Repair [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2007.
2017	Torstrick FB. Effects of Surface Chemistry and Surface Topography on Polyether-Ether-Ketone Osseointegration [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2017.
2009	Lan SK. Multi-Scale Osteointegration and Neovascularization of Biphasic Calcium Phosphate Bone Scaffolds [PhD thesis]. University of Illinois at Urbana-Champaign; 2009.
2011	Hoelzle DJ. Flexible Adaptation of Iterative Learning Control With Applications to Synthetic Bone Graft Manufacturing [PhD thesis]. University of Illinois at Urbana-Champaign; 2011.
2009	Moesen M. Modeling of the Geometry and Mechanical Behavior of Bone Scaffolds [PhD thesis]. Leuven, Belgium: Katholieke Universiteit Leuven; June 2009.
2017	Tedesco J. Multi-Scale Characterization of Biomaterials Using Complementary X-Ray and Electron Imaging Techniques [Master's thesis]. Hamilton, ON: McMaster University; September 2017.
2017	Wang Y-F. Enhancement of Nutrient Transport and Energy Production of the Intervertebral Disc by the Implantation of Polyurethane Mass [PhD thesis]. University of Miami; August 2017.
2019	Neves E. The Effect of Strain on the Minerlization of Individual Collagen Fibrils [Master's thesis]. Northeastern University; December 2019.
2017	Meinert AC. Hydrogels and Bioreactors for Cartilage Research and Functional Tissue Engineering [PhD thesis]. Queensland University of Technology; 2017.
2019	Forrestal DP. Flow Control in Perfusion Bioreactors for Improved Cell Culture Within Porous Tissue Scaffolds [PhD thesis]. Queensland University of Technology; 2019.
2013	Viswanathan P. In Situ Surface Functionalisation of Scaffolds Using Block Copolymer Self-Assembly [PhD thesis]. University of Sheffield; 2013.
2017	Owen R. Tissue Engineering an in Vitro Model of Osteoporosis [PhD thesis]. Sheffield, UK: University of Sheffield; October 2017.
2010	Lee WJ. Liver Tissue Engineering Based on Poly (ethylene Glycol) Hydrogels [PhD thesis]. Stanford University; March 2010.
2014	Rode NA. Design of Electrospun Hydrogel Fibers Containing Multivalent Peptide Conjugates for Cardiac Tissue Engineering [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2014.
2014	Hadidi P. Enhancing the Biochemical and Mechanical Properties of a Self-Assembling Scaffold-Free Tissue Engineered Knee Meniscus [PhD thesis]. Davis, University of California; 2014.
2008	Rosines E. Developmental Approaches to in Vitro Engineering of Kidney-Like Tissues [PhD thesis]. San Diego (UCSD), University of California; 2008.
2006	Jongpaiboonkit L. Calcium Phosphate Scaffolds for Bone Tissue Engineering and Self-Association PEG-PLLA Diblock Copolymer for Controlled Drug Delivery System [PhD thesis]. University of Michigan; 2006.
2007	Liao EE. Enhancement of Chondrogenesis by Directing Cellular Condensation Through Chondroinductive Microenvironments, And, Designed Solid Freeform Fabricated Scaffolds [PhD thesis]. University of Michigan; 2007.
2007	Wong DY. Anatomically Inspired Scaffold Design Enhances Tissue Regeneration in Brain and Spinal Cord [PhD thesis]. University of Michigan; 2007.
2008	Kemppainen JM. Mechanically Stable Solid Freeform Fabricated Scaffolds With Permeability Optimized for Cartilage Tissue Engineering [PhD thesis]. University of Michigan; 2008.
2010	Jeong GC. The Effects of Designed Scaffold Architecture and Biodegradable Material on Chondrogenesis in Vitro and in Vivo [PhD thesis]. University of Michigan; 2010.
2010	Kang HS. Hierarchical Design and Simulation of Tissue Engineering Scaffold Mechanical, Mass Transport, and Degradation Properties [PhD thesis]. University of Michigan; 2010.
2011	Saito E. Designed Biodegradable and Osteoconductive Porous Scaffolds for Human Trabecular Bone [PhD thesis]. University of Michigan; 2011.
2011	Vivanco Morales JF. Investigation of Fabrication and Environmental Effects on Bioceramic Bone Scaffolds [PhD thesis]. University of Wisconsin – Madison; 2011.