Most micro-CT finite element modeling of human trabecular bone has focused on linear and non-linear analysis to evaluate bone failure properties. However, prediction of the apparent failure properties of trabecular bone specimens under compressive load, including the damage initiation and its progressive propagation until complete bone failure into consideration, is still lacking. In the present work, an isotropic micro-CT FE model at bone tissue level coupled to a damage law was developed in order to simulate the failure of human trabecular bone specimens under quasi-static compressive load and predict the apparent stress and strain. The element deletion technique was applied in order to simulate the progressive fracturing process of bone tissue. To prevent mesh-dependence that generally affects the damage propagation rate, regularization technique was applied in the current work. The model was validated with experimental results performed on twenty-three human trabecular specimens. In addition, a sensitivity analysis was performed to investigate the impact of the model factors' sensitivities on the predicted ultimate stress and strain of the trabecular specimens. It was found that the predicted failure properties agreed very well with the experimental ones.