Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels

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Eriksen, Erik F.¹; Hodgson, Stephen F.¹; Eastell, Richard¹; Cedel, Sandra L.²; O'Fallon, W. Michael²; Riggs, B. Lawrence¹

Cancellous bone remodeling in type I (postmenopausal) osteoporosis: quantitative assessment of rates of formation, resorption, and bone loss at tissue and cellular levels

J Bone Miner Res. April 1990;5(4):311-319

Affiliations

¹Endocrine Research Unit, Division of Endocrinology, Metabolism, and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MD 55905

²Section of Biostatistics, Mayo Clinic and Mayo Foundation, Rochester, MN 55905
Abstract

The cellular mechanisms for bone loss in type I (postmenopausal) osteoporosis are highly controversial. We attempted to resolve this by assessing rates of formation and resorption of iliac cancellous bone by a new histomorphometric method in 89 women with osteoporosis (mean age + SD, 66 + 6 years) and in 32 carefully selected normal postmenopausal women (64 + 6 years). In the osteoporotic women, bone resorption rate was increased by 39% (P <0.05) at the cellular level and by 67% (P <0.05) at the tissue level, whereas bone formation was unchanged at the tissue level but decreased by 14% (P <0.01) at the cellular (osteoblast) level. This pronounced remodeling imbalance (P <0.001) was probably exacerbated by a 45% increase (P < 0.1) in activation frequency of new remodeling foci. These abnormalities were associated with a high rate of cancellous bone loss (median, 5.8%/year versus 0.1%/year in controls). Thus, accelerated loss of cancellous bone in type I osteoporosis results from the combination of increased bone resorption and inadequate compensation by bone formation.
Links

DOI: 10.1002/jbmr.5650050402

PubMed: 2343771

WoS: A1990DA70000001
History

Received: 1989-03-28

Revised: 1989-09-28

Accepted: 1989-10-11

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