Bone microdamage and skeletal fragility in osteoporotic and stress fractures

Burr, David B.; Forwood, Mark R.; Fyhrie, David P.; Martin, R. Bruce; Schaffler, Mitchell B.; Turner, Charles H.

Year	Entry
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1997	Mori S, Harruff R, Ambrosius W, Burr DB. Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures. Bone. December 1997;21(6):521-526.
1998	Boyde A, Compston JE, Reeve J, Bell KL, Noble BS, Jones SJ, Loveridge N. Effect of estrogen suppression on the mineralization density of iliac crest biopsies in young women as assessed by backscattered electron imaging. Bone. March 1998;22(3):241-250.
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2001	Mashiba T, Turner CH, Hirano T, Forwood MR, Johnston CC, Burr DB. Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles. Bone. May 2001;28(5):524-531.
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2010	Tang SY, Vashishth D. Non-enzymatic glycation alters microdamage formation in human cancellous bone. Bone. January 2010;46(1):148-154.
2011	Tjhia CK, Odvina CV, Rao DS, Stover SM, Wang X, Fyhrie DP. Mechanical property and tissue mineral density differences among severely suppressed bone turnover (SSBT) patients, osteoporotic patients, and normal subjects. Bone. December 2011;49(6):1279-1289.
2014	Hernandez CJ, Lambers FM, Widjaja J, Chapa C, Rimnac CM. Quantitative relationships between microdamage and cancellous bone strength and stiffness. Bone. September 2014;66:205-213.
2005	Seref-Ferlengez Z, Kennedy OD, Schaffler MB. Bone microdamage, remodeling and bone fragility: how much damage is too much damage? BoneKEy Rep. March 18, 2005;4:644.
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2020	Mirzaali MJ, Libonati F, Böhm C, Rinaudo L, Cesana BM, Ulivieri FM, Vergani L. Fatigue-caused damage in trabecular bone from clinical, morphological and mechanical perspectives. Int J Fatigue. April 2020;133:105451.
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2002	Arthur Moore TL, Gibson LJ. Microdamage accumulation in bovine trabecular bone in uniaxial compression. J Biomech Eng. February 2002;124(1):63-71.
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2000	Akkus O. The Relation of Microdamage to Fracture and Material Property Degradation in Human Cortical Bone Tissue [PhD thesis]. Cleveland, OH: Case Western Reserve University; August 2000.
2003	Bredbenner TL. Damage Modeling of Vertebral Trabecular Bone [PhD thesis]. Cleveland, OH: Case Western Reserve University; January 2003.
2006	Joo W. Cross-Modal Effects of Damage on Mechanical Behavior of Human Cortical Bone [PhD thesis]. Cleveland, OH: Case Western Reserve University; January 2006.
2006	Warden KE. Localized Trabecular Damage Adjacent to Interbody Fusion Devices [PhD thesis]. Cleveland, OH: Case Western Reserve University; May 2006.
2010	Dux SJ. The Effect of Gamma Radiation Sterilization on Yield Properties and Microscopic Tissue Damage in Dense Cancellous Bone [Master's thesis]. Cleveland, OH: Case Western Reserve University; January 2010.
2010	Ramsey DS. Effects of Gamma Irradiation on the Damage Processes in Human Trabecular Bone [Master's thesis]. Cleveland, OH: Case Western Reserve University; October 2010.
2011	Kummari SR. Experimental and Computational Evaluation of Microscopic Tissue Damage and Remodeling Cavities in Trabecular Bone [PhD thesis]. Cleveland, OH: Case Western Reserve University; May 2011.
2012	Moore E. The Frequency, Aqueous Solution, Stress Amplitude, Temperature (FAST) Machine: A Device Proposed for Accelerated Fatigue Testing of Cortical Bone [Master's thesis]. Cleveland, OH: Case Western Reserve University; August 2012.
2012	Slyfield CR Jr. The Biomechanics of Bone Turnover [PhD thesis]. Ithaca, NY: Cornell University; January 2012.
2015	Goff M. The Role of Micro and Ultra-Structure in Microdamage Accumulation in Cancellous Bone [PhD thesis]. Ithaca, NY: Cornell University; August 2015.
2018	Torres AM. Fatigue Behavior of Cancellous Bone, Microdamage Accumulation, and Biologically Inspired Cellular Solids [PhD thesis]. Ithaca, NY: Cornell University; August 2018.
2018	Xie S. Characterisation of Time-Dependent Mechanical Behaviour of Trabecular Bone and Its Constituents [PhD thesis]. Edinburgh, Scotland: University of Edinburgh; 2018.
2006	Nagaraja S. Microstructural Stresses and Strains Associated With Trabecular Bone Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
2010	Wang JL. Effects of Aging and Remodeling on Bone Microdamage Formation [Master's thesis]. Atlanta, GA: Georgia Institute of Technology; December 2010.
2011	O'Neal JM. The Effects of Aging and Remodeling on Bone Quality and Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2011.
2018	Yan C. Effect of Fatigue Loading on Impact Response of Rat Ulna [Master's thesis]. Urbana, IL: University of Illinois at Urbana-Champaign; 2018.
2001	Arthur Moore TL. Microdamage Accumulation in Bovine Trabecular Bone [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2001.
2007	Tai K. Nanomechanics and Ultrastructural Studies of Cortical Bone: Fundamental Insights Regarding Structure-Function, Mineral-Organic Force Mechanics Interactions, and Heterogeneity [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2007.
2015	Oftadeh R. Hierarchical Analysis and Multiscale Modelling of Cellular Structures: From Meta Materials to Bone Structure [PhD thesis]. Boston, MA: Northeastern University; December 2015.
2004	Tovar A. Bone Remodeling as a Hybrid Cellular Automaton Optimization Process [PhD thesis]. Notre Dame, IN: University of Notre Dame; December 2004.
2004	Wang X. Measurement and Analysis of Microdamage in Bone [PhD thesis]. University of Notre Dame; December 2004.
2010	Shi X. Effects of Architecture on Microdamage Susceptibility in Trabecular Bone [PhD thesis]. University of Notre Dame; April 2010.
2011	Garrison JG. The Relative Importance of Stress State, Microarchitecture, and Damage Burden in the Failure Behavior of Trabecular Bone [PhD thesis]. Notre Dame, Indiana: University of Notre Dame; April 2011.
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2015	Gargac J. Evaluation of Bone Healing, Damage, and Adaptation Using Computational Modeling and Image Processing Techniques [PhD thesis]. University of Notre Dame; July 2015.
2017	Kreipke TC. Structural, Mechanical, and Biological Relationships of Trabecular Bone in Osteoporosis [PhD thesis]. Notre Dame, IN: University of Notre Dame; April 2017.
2020	O’Sullivan LM. Time-Sequence of Biomechanical Adaption in Trabecular Tissue During Estrogen Deficiency [PhD thesis]. National University of Ireland Galway; March 2020.
2011	Agnew AM. Histomorphometry of the Elderly Rib: A Methodological Approach With Implications for Biomechanics, Function, and Fracture Risk [PhD thesis]. Columbus, OH: Ohio State university; 2011.
2012	Sun X. Mechanically Induced Calcium Efflux from Bone Matrix Stimulates Osteoblasts [PhD thesis]. Purdue University; May 2012.
2015	Clauser CA. In Vivo Tibial Loading of Healthy and Osteolathrytic Mice [Master's thesis]. Indianapolis, IN: Purdue University; May 2015.
2012	Jimenez Palomar I. Mechanical Properties of Bone At the Sub-lamellar Level [PhD thesis]. London, England: Queen Mary University of London; September 2012.
2013	Toal VR. The Mechanics of Microdamage and Microfracture in Trabecular Bone [PhD thesis]. Brisbane, Australia: Queensland University of Technology; September 2013.
2005	George WT. Multiaxial Fracture Characteristics of Aging Human Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2005.
2006	Diab T. The Role of Damage Morphology in Age-Related Increase in Bone Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; 2006.
2010	Janeiro C. The Effect of Bone Quality on Osteoclastic Bone Resorption [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; May 2010.
2011	Karim L. The Biomolecular Basis of Bone Fracture [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; November 2011.
2014	Bradke BS. The Role of Cortical and Cancellous Bone Quality on Vertebral Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2014.
2018	Alousaimi H. A Study of Bone Quality in Femoral Neck of Osteoarthritis [Master's thesis]. Vancouver, BC: University of British Columbia; August 2018.
2017	Fung A. Experimental Validation of Finite Element Predicted Bone Strain in the Human Metatarsal [Master's thesis]. Calgary, AB: University of Calgary; April 2017.
2002	Morgan EF-i. The Dependence on Anatomic Site of Trabecular Bone Structure-Function Relationships [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2002.
1999	Donahue SW. Bone Strain and Microdamage At Stress Fracture Sites in Human Metatarsals [PhD thesis]. Davis, University of California; 1999.
2003	Nyman JS. Simulations of Bone Adaptation to Total Knee Arthroplasty and Bisphosphonates Through Remodeling Stimulated by Microdamage and Disuse [PhD thesis]. Davis, University of California; 2003.
2012	Hardisty MR. Not Tough Enough: Why Bone Turns Pale When it Feels Stressed [PhD thesis]. Davis, CA: Davis, University of California; 2012.
2012	Tjhia CKH. Bone Quality of Patients With Atypical Fractures and Severely Suppressed Bone Turnover [PhD thesis]. Davis, University of California; 2012.
2013	Wang Y-K. Multi-Level Micromechanical Modeling of Bone Tissues [PhD thesis]. Los Angeles, CA: Los Angeles, University of California; 2013.
2016	Jones DA. Reference Point Indentation of Human Trabecular Bone Treated With Bisphosphonates for Varying Durations [Master's thesis]. Lexington; KY: University of Kentucky; 2016.
1998	Ciarelli TE. Architectural and Material Contributions to Fracture of the Spine and Proximal Femur [PhD thesis]. Ann Arbor, MI: University of Michigan; 1998.
2003	Rajachar RM. Effects of Age -Related Ultra-Structural Level Changes in Bone on Microdamage Mechanisms [PhD thesis]. University of Michigan; 2003.
2007	Wallace JM III. Investigating the Inbred Strain-Specific Response to Biglycan-Deficiency and Exercise: A Study in Genetically-Mediated Skeletal Adaptation [PhD thesis]. University of Michigan; 2007.
2008	Waldorff EI. Effects of Aging and Disuse on Bone Remodeling in Response to Microdamage [PhD thesis]. University of Michigan; 2008.
2009	Sahar ND. Investigating the Effects of Age and Exercise on Bone Composition and the Impact of Composition on Mechanical Integrity. [PhD thesis]. University of Michigan; 2009.
2010	Wynnyckyj C. The Consequences of Collagen Degradation on Bone Mechanical Properties [PhD thesis]. Toronto, ON: University of Toronto; 2010.
2009	Nakade R. Influence of Interfacial Properties and Inhomogeneity on Formation of Microdamage in Bone [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; December 2009.
2010	Banka M. Microdamage Induced Collagen Denaturation in Bone [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; December 2010.
2010	Reyes MJ. Age-Related Influence of Bone Remodeling on Local Tissue Properties of Human Cortical Bone [PhD thesis]. San Antionio, TX: University of Texas at San Antonio; December 2010.
2013	Mahmud K. Intrafibrillar Damage Accumulation & the Contribution of Extrafibrillar Mineral to Bone Elastic Modulus [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; August 2013.
2013	Mostafa AJ. The Effect of Advadvanced Glycation Endproducts (AGES) on Bone Formation [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; August 2013.
1998	Yeni YN. Fracture Mechanics of Human Cortical Bone: The Relationship of Geometry, Microstructure and Composition With the Fracture of the Tibia, Femoral Shaft and the Femoral Neck [PhD thesis]. Morgantown, WV: West Virginia University; 1998.
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Year	Entry
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