The design and fabrication for fast paced production of microfluidic chips have significant implications for lung airway research, providing a scalable and cost-effective solution for in vitro modeling. This study is aimed to explore different fabrication methods for creating these microfluidic chips, focusing on optimizing the existing design. Using Fusion360, CAD files were created to enhance the precision and functionality for specific fabrication types. Microinjection molding was explored with the highest cost involved but with the fastest production speeds. Hot embossing and laser cutting was designed as a medium economic choice while sacrificing fabrication pace. 3D printing was investigated and experimented with the potential of low volume production options being viable at a higher rate of defects. Ultimately all these were compared to the original fabrication process of micro milling the microfluidic devices on precut wafers, and the consensus was with low volume production the continuation of micro milling is effective. The medium volume production solution is hot embossing with laser cutting and highvolume production option is injection molding with laser cutting. The findings demonstrate that the new designs and fabrication processes improve the production and scale up manufacturability of the microfluidic chips. This advancement offers a promising tool for researchers in lung airway studies, potentially accelerating the development of treatments for respiratory diseases.