The population and economic growth experienced by Canadian metropolitan areas in the past twenty years, has been associated with increased levels of car ownership and vehicle kilometres travelled leading to a deterioration of air quality and public health and an increase in greenhouse gas emissions. The need to modify urban growth patterns has motivated planning agencies in Canada to develop a broad range of policies aiming at achieving a more sustainable transportation sector. The challenge however, remains in the ability to test the effectiveness of proposed policy measures. This situation has led to a renewed interest in integrated land-use and transport models to support transport policy appraisal. This research is motivated by the need to improve transport policy appraisal through the use of integrated land-use and transport models linked with a range of sub-models that can reflect transport externalities. This research starts with an exploration of the transport policy environment in Canada through a questionnaire-based survey conducted with planners and policy-makers. The survey results highlight the need for tools reflecting the sustainability impacts of proposed policies. While the second part of this research explores sustainability indicators and recommends a set of social, economic, and environmental measures, linked with integrated land-use and transport models;​ effort is dedicated to estimate the environmental indicators as part of this thesis. As such, the third part of this research involves the development of an emission-dispersion-exposure modelling framework. The framework includes a suite of sub-models including an activity-based travel demand model (TASHA), an emission factor model (Mobile6.2C), a meteorological model (CALMET), and a dispersion model (CALPUFF). The framework is used to estimate link-based emissions of light-duty vehicles in the Greater Toronto Area under a base scenario for 2001. Dispersion of emissions is then conducted and linked with population in order to estimate exposure to air pollution.