In this thesis, a comprehensive meat supply chain (MSC) planning problem is studied. We consider live animals, chilled and frozen meat products as it is in the real case in most meat supply chain industries. A literature review is presented, and optimizationbased method has been proposed in food supply industries. Two mathematical models are proposed considering comprehensive meat supply chain problems. The considered meat supply chain problem was decomposed into two optimization sub-problems. The approach is to use two separate mathematical models for solving each sub-problem. The developed mathematical models are examined on a practical system in a meat supply chain company based in United Arab Emirates. The heuristic solution approach is introduced to solve the comprehensive meat supply chain optimization model developed. It can generate a good solution for all tested example problems with much reduced computational time.