Paper has emerged as a desirable substrate material for the development of flexible electronics and sensors as it offers several advantages such as low cost, biodegradability, disposability, ease of fabrication, good printability, high flexibility and light weight. Moreover, by integrating functional nanomaterials such as zinc oxide nanowires (ZnO NWs) through a low temperature wet chemical approach on paper substrates, it expands the functionalities and potential of utilizing paper as a sensing element. In this work, a paper-based accelerometer and a paper-based touch pad were developed and characterized. Both prototypes utilized the piezoelectric properties of ZnO NWs on paper: piezoelectric charges are generated as the NWs on the paper substrate experience mechanical deformation. As the electrical output of the ZnO NWs were typically on the order of pico-amperes, charge amplifier circuits were designed for both prototypes. For the first part of the thesis, the paper-based accelerometer employs a cantilever-based configuration, and with a proof mass of 61 mg, a sensitivity of 16 mV/g and a natural frequency of 74.85 Hz were achieved. For the second part of the thesis, the paper-based touch pad is a monolithic single-layer device with pixels of touch sensors (essentially islands of ZnO NWs) on it for touch sensing.