Neural stem and progenitor cells (neural precursors) exist within the adult mammalian central nervous system, primarily within the brain’s neurogenic subependymal and subgranular zones, and in the lining of the spinal cord central canal. Neural precursors are ideal candidates for cell replacement strategies, due to their multipotency and neural stem cells’ inherent capacity for self-renewal. Indeed, following neural insult such as ischaemia, endogenous subependymal neural precursors undergo a proliferative and migratory response, whereby they migrate toward the lesion site and differentiate into neural cells. With the goal of enhancing this migratory response in order to facilitate improved neural repair, the work in this thesis has focused on utilizing electrical fields to direct and enhance neural precursor migration and understanding the mechanisms that underlie the effects. We have shown for the first time that primary undifferentiated neural precursors from the adult mammalian brain undergo rapid and cathodedirected migration in the presence of an electrical field, a phenomenon known as galvanotaxis. Strikingly, this response is entirely absent in neural precursors that are induced to differentiate into mature phenotypes. We utilized cross-perfusion techniques to demonstrate that the migratory response is not the result of a chemical gradient that may be electrophoretically generated within the culture media, establishing that the migration is a direct response of the applied electrical field. Second, we have provided evidence that neural precursor galvanotaxis is mediated by epidermal growth factor receptor signalling – one of the mitogens that maintains neural precursors in an undifferentiated state – and by Ca²⁺. Suppressing either epidermal growth factor or Ca²⁺ signalling resulted in attenuation in the migration rate of galvanotaxis, without affecting the cells’ directedness. Importantly, we also demonstrate that neural precursor galvanotaxis can be induced via charge-balanced biphasic electrical pulses – a stimulation paradigm that is deemed safe for clinical neural stimulation applications. Overall, the work presented herein demonstrates the potential of incorporating galvanotaxis into the development of neural repair strategies as a mechanism for controlling the rate and direction of migration. This thesis contains supplementary content in the form of video files that are referenced throughout the text by the prefix ‘Movie S’ followed by the file number (for example Movie S1, Movie S2).