The field of two-dimensional nano materials has gained significant interest over last few decades in numerous applications due to their unique properties that exhibit when a bulk material is reduced to its 2D form. A wide variety of 2D layered materials are synthesized by newly developed compressible flow exfoliation (CFE) process which has considerable advantages over current top-down approaches. In this study, classical molecular dynamics (MD) simulations are used to investigate the interactions of gas particles with pristine, unfunctionalized graphene sheets during CFE process and try to understand the atomistic mechanism of layer separation. Thermal vibration of graphene layers increases with the elevation of temperature which accelerate the exfoliation tendency;​ but the presence of static gas particles is insignificant here because of their lower binding energy. Range of one-directional flow velocities are injected to the compressible gases to replicate the experimental situation and dispersion of graphene is observed when the velocity exceeds the supersonic flow condition. Analyzing dynamic properties of exfoliation, it is established that sliding or parallel direction is preferable exfoliation mechanism of graphene than vertical separation. Besides, the inlet pressure plays a fundamental role because gas density and flow velocity are associated with that. It is also observed that heavier gas has less susceptible to delaminate graphene because of their higher atomic mass and lower flow rate at identical condition. The findings of this study provide more flexibility to synthesize not only graphene but any two-dimensional materials using compressible gases.