Tibiotalocalcaneal (TTC) arthrodesis is a salvage procedure for patients with severe osteoarthritis and other severe ankle conditions. The procedure is done by inserting an intramedullary (IM) nail through bottom of the calcaneus and up through the talus and the tibia. The nail is fixed with several screws and compression is applied by the nail and screws to the three bones in order to promote fusion. The purpose of this study is to compare different IM nails in a simulated ankle fusion using Finite Element Analysis (FEA). A pseudo-elastic, conventional titanium, and conventional carbon-fiber nail were all tested for load sharing between the nail body and the tibia under gait loading and compression with a resorption zone. A model of the bones was generated from a quantitative computed tomography (QCT) scan of a healthy leg. Pseudo-elastic compression was simulated by pre-stretching the pseudo-elastic compressive element in the by itself and then inserting it into the nail jacket. The conventional static nails, were compressed by giving the nail jacket an orthotropic thermal expansion coefficient and reducing the temperature in the model. After compression, each nail was subjected to an applied gait load. In the pseudo-elastic model, the tibia was subjected to 68% of the peak load during the gait cycle. The titanium and carbon-fiber nail models had tibia load values of 23% and 28%, respectively. The resorption for each model was simulated using a layer of bone in the talus with varying Young’s Moduli and a Poisson’s ratio of 0.01. For the static nails, the amount of compression provided by the nail drops more than 80% when exposed to a prescribed resorption zone. The pseudo-elastic nail maintains compression when exposed to resorption up to 4% of the “locked” strain value.