Types I and II collagens in intervertebral disc:​ interchanging radial distributions in annulus fibrosus

Eyre, David R.; Muir, Helen

Affiliations

¹Biochemistry Division, Kennedy Institute of Rheumatology, Bute Gardens, Hammersmith, London W6 7DW, U.K.

Abstract

Intervertebral disc is a highly specialized cartilaginous tissue, containing two genetic types of collagen (I and II). Analysis of peptides from a CNBr digest of collagen showed that the proportions of I and II varied gradually and inversely across pig annulus fibrosus, with exclusively type I at the extreme outer edge and exclusively type II in the nucleus pulposus.

Links

DOI: 10.1042/bj1570267

PubMed: 962859

History

Received: 1976-04-12

Cited By (36)

Year	Entry
1979	Muir IHM. Biochemistry. In: Freeman MAR, ed. Adult Articular Cartilage. 2nd ed. Kent, England: Pitman Medical; 1979:145-214.
2005	Holzapfel GA, Schulze-Bauer CAJ, Feigl G, Regitnig P. Single lamellar mechanics of the human lumbar anulus fibrosus. Biomech Model Mechanobiol. March 2005;3(3):125-140.
1998	Errington RJ, Puustjarvi K, White IRF, Roberts S, Urban JPG. Characterisation of cytoplasm-filled processes in cells of the intervertebral disc. J Anat. April 1998;192(3):369-378.
1996	Antoniou J, Steffen T, Nelson F, Winterbottom N, Hollander AP, Poole RA, Aebi M, Alini M. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest. August 15, 1996;98(4):996-1003.
1984	Brickley-Parsons D, Glimcher MJ. Is the chemistry of collagen in intervertebral discs an expression of Wolff's Law? a study of the human lumbar spine. Spine. March 1984;9(2):148-163.
1994	Best BA, Guilak F, Setton LA, Zhu W, Saed-Nejad F, Ratcliffe A, Weidenbaum M, Mow VC. Compressive mechanical properties of the human anulus fibrosus and their relationship to biochemical composition. Spine. January 15, 1994;19(2):212-221.
1994	Skaggs DL, Weidenbaum M, Iatridis JC, Ratcliffe A, Mow VC. Regional variation in tensile properties and biochemical composition of the human lumbar anulus fibrosus. Spine. June 15, 1994;19(12):1310-1319.
1996	Iatridis JC. Biomechanics of the Anulus Fibrosus and Nucleus Pulposus of the Human Lumbar Intervertebral Disc and the Effects of Degeneration [PhD thesis]. Columbia University; 1996.
2019	Qu D. Tissue Engineering Strategies for Fibrocartilage Interface Regeneration [PhD thesis]. Columbia University; 2019.
2021	Lintz M. Tissue Engineering Strategies for Total Disc Replacement: Structure and Mechanical Function of the Intervertebral Disc [PhD thesis]. Ithaca, NY: Cornell University; August 2021.
2012	Rao M. Explicit Finite Element Modeling of the Human Lumbar Spine [PhD thesis]. University of Denver; November 2012.
1999	Elliott DM. The Fiber-Induced Anisotropic Material Behaviors of the Anulus Fibrosus of the Intervertebral Disc in Tension [PhD thesis]. Duke University; 1999.
2008	Cao L. Micromechanics of the Pericellular Matrix and Cells in the Intervertebral Disc: Three-Dimensional Finite Element Modeling Based on in Situ Morphology [PhD thesis]. Duke University; 2008.
2015	Bridgen DT. Regulation of Human Nucleus Pulposus Cell Phenotype and Behavior by Laminin-Mimetic Peptide Substrates [PhD thesis]. Duke University; 2015.
2015	Nimeskern LG. Functional Characterization of Auricular Cartilage in Tissue Engineering and Regenerative Medicine [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2015.
2020	Widmer J. Patient Specific Material Mapping for Functional Outcome Prediction and Planning in Spinal Surgery [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2020.
2016	Gao X. Modeling the Biomechanics and Mechanobiology of Intervertebral Discs [PhD thesis]. University of Miami; August 2016.
2020	Yin X. ATP Metabolism of Intervertebral Disc Cells Under Physiological Nutritional Conditions [PhD thesis]. University of Miami; May 2020.
2019	Torre OM. Intervertebral Disc Regeneration in Neonatal Mice [PhD thesis]. Icahn School of Medicine at Mount Sinai; 2019.
2022	Gallate ZS. Galectin-3 Mediates Advanced Glycation Endproduct-Induced Collagen Damage in Intervertebral Discs [Master's thesis]. Icahn School of Medicine at Mount Sinai; 2022.
2022	Panebianco CJ. Engineering Composite Hydrogels and Discovering Novel Cell Populations for Next-Generation Intervertebral Disc Repair [PhD thesis]. Icahn School of Medicine at Mount Sinai; March 2022.
2017	Lowe J. SIS-ECM Scaffold Remodels Into a TMJ Disc Analogue [PhD thesis]. University of Pittsburgh; 2017.
2016	Hachem B. Porcine Spine Finite Element Model of Progressive Experimental Scoliosis and Assessment of a New Dual-Epiphyseal Growth Modulating Implant [PhD thesis]. École polytechnique de Montréal; April 2016.
2006	Patel KP. Effect of PH on the Metabolism of Proteoglycans in the Intervertebral Disc: Investigation in an in Vitro Model With IL-1 Alpha Stimulation and Confirmation in the Cadaveric Human Intervertebral Disc [PhD thesis]. Rush University; 2006.
2019	Bezci SE. Time-Dependent Characterization of Fluid Flow Into the Intervertebral Disc [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2019.
2019	Yang B. Simulating Intervertebral Disc Mechanics Using Finite Element Method [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2019.
2011	Cheng KK-W. Diminished Matrix in Pathologic Intervertebral Discs and Tissue Engineered Solutions [PhD thesis]. San Francisco, University of California; 2011.
2013	Laws CJ. Mechanisms of Disc Herniation in Astronauts Following Spaceflight [PhD thesis]. San Francisco, University of California; 2013.
2021	Iriondo C. Characterizing Phenotypes of Musculoskeletal Degeneration Using Medical Imaging and Deep Learning [PhD thesis]. San Francisco, University of California; 2021.
2009	O'Connell GD. Degeneration Affects the Structural and Tissue Mechanics of the Intervertebral Disc [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2009.
2014	Yoder JH. Intervertebral Disc Structure and Mechanical Function Under Physiological Loading Quantified Non-Invasively Utilizing MRI and Image Registration [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2014.
2015	Han WJ. Mechanical Strain Transfer and Calcium Signaling in Fiber-Reinforced Musculoskeletal Soft Tissues [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2015.
2009	Gregory DE. The Influence of the Tensile Material Properties of Single Annulus Fibrosus Lamellae and the Interlamellar Matrix Strength on Disc Herniation and Progression [PhD thesis]. University of Waterloo; 2009.
2009	Yates JP. Establishing the Effect of Vibration and Postural Constraint Loading on the Progression of Intervertebral Disc Herniation [Master's thesis]. University of Waterloo; 2009.
2014	Gooyers CE. Exploring Interactions Between Force, Repetition and Posture on Low Back Joint Loading and Intervertebral Disc Injury [PhD thesis]. University of Waterloo; 2014.
1997	Rapoff AJ. Tensile Fatigue of Intervertebral Disc Annulus and a Probabilistic Rule of Mixtures for Elastic Moduli [PhD thesis]. University of Wisconsin – Madison; August 1997.