Due to the fast growth in industry and in order to reduce manufacturing budget, increase the quality of products and increase the accuracy of manufactured products in addition to assure the safety of workers, people relied on mechanisms for such purposes. Recently, cable driven parallel mechanisms (CDPMs) have attracted much attention due to their many advantages over conventional parallel mechanisms, such as the significantly large workspace and the dynamics capacity. In addition, it has lower mass compared to other parallel mechanisms because of its negligible mass cables compared to the rigid links. In many applications it is required that human interact with machines and robots to achieve tasks precisely and accurately. Therefore, a new domain of scientific research has been introduced, that is human robot interaction, where operators can share the same workspace with robots and machines such as cable driven mechanisms. One of the main requirements due to this interaction that robots should respond to human actions in accurate, harmless way. In addition, the trajectory of the end effector is coming now from the operator and it is very essential that the initial trajectory is kept unchanged to perform tasks such assembly, operating or pick and place while avoiding the cables to interfere with each other or collide with the operator. Accordingly, many issues have been raised such as control, vibrations and stability due the contact between human and robot. Also, one of the most important issues is to guarantee collision free space (to avoid collision between cables and operator and to avoid collisions between cables itself). The aim of this research project is to model, design, analysis and implement reconfigurable six degrees of freedom parallel mechanism driven by eight cables. The main contribution of this work will be as follow. First, develop a nonlinear model and solve the forward and inverse kinematics issue of a fully constrained CDPM given that the attachment points on the rails are moving vertically (conventional cable driven mechanisms have fixed attachment points on the rails) while controlling the cable lengths. Second, the new idea of reconfiguration is then used to avoid interference between cables and between cables and operator limbs in real time by moving one cable’s attachment point on the frame to increase the shortest distance between them while keeping the trajectory of the end effector unchanged. Third, the new proposed approach was tested by creating a simulated intended cable-cable and cable-human interference trajectory, hence detecting and avoiding cable-cable and cable-human collision using the proposed real time reconfiguration while maintaining the initial end effector trajectory. Fourth, study the effect of relocating the attachment points on the constant-orientation wrench feasible workspace of the CDPM.