Treatment of infected orthopaedic implants often require two separate surgeries to clear the infection and install a replacement implant. Current antimicrobial drug delivery methods are inefficient, and each additional surgery increases the physiologic burden on patients, with an increased risk of infection, decreased range of motion and longer recovery times. Porous orthopaedic implants, with adequate strength for permanent implantation and the ability to house and elude more efficient antibiotic delivery systems, could result in a single surgery to treat orthopaedic infections. Therefore, finite element models of porous gyroid structures at different porosities were developed and compared with experimental results. Discrepancies in predicted and actual apparent elastic moduli and fatigue lives were found due to anomalies caused from the 3D-printing of the specimens, however, similar relationships across porosities were observed. A case study of a porous gyroid humeral stem was created to evaluate the mechanical capabilities of the porous stems as well as their impact on humerus mechanobiology. The porous stems were found to exhibit adequate strength in three different bone densities during four different arm motions. Some evidence of improved bone remodelling behaviours was observed when comparing the effects of the porous stems versus a traditional solid stem.