Reversible effects of puberty suppression on bone strength, mass, and body composition in adolescent mice after testosterone therapy

Affiliations

¹Trans Health Research Group, The University of Melbourne, Heidelberg, Australia

²Department of Endocrinology, Austin Health, Heidelberg, Australia

Links

History

Received: 2023-07-06

Revised: 2023-08-06

Accepted: 2023-08-13

Cited Works (5)

Year	Entry
2013	Jilka RL. The relevance of mouse models for investigating age-related bone loss in humans. J Gerontol A Biol Sci Med Sci. October 2013;68(10):1209-1217.
2020	Chapurlat R, Bui M, Sornay‐Rendu E, Zebaze R, Delmas PD, Liew D, Lespessailles E, Seeman E. Deterioration of cortical and trabecular microstructure identifies women with osteopenia or normal bone mineral density at imminent and long‐term risk for fragility fracture: a prospective study. J Bone Miner Res. May 2020;35(5):833-844.
2020	Wiepjes CM, de Blok CJM, Staphorsius AS, Nota NM, Vlot MC, de Jongh RT, den Heijer M. Fracture risk in trans women and trans men using long‐term gender‐affirming hormonal treatment: a nationwide cohort study. J Bone Miner Res. January 2020;35(1):64-70.
2022	Bretherton I, Ghasem-Zadeh A, Leemaqz SY, Seeman E, Wang X, McFarlane T, Spanos C, Grossmann M, Zajac JD, Cheung AS. Bone microarchitecture in transgender adults: a cross-sectional study. J Bone Miner Res. April 2022;37(4):643-648.
2023	Dubois V, Ciancia S, Doms S, Kharraz SE, Sommers V, Kim NR, David K, Van Dijck J, Valle-Tenney R, Maes C, Antonio L, Decallonne B, Carmeliet G, Claessens F, Cools M, Vanderschueren D. Testosterone restores body composition, bone mass, and bone strength following early puberty suppression in a mouse model mimicking the clinical strategy in trans boys. J Bone Miner Res. October 2023;38(10):1497-1508.